Results 61 to 70 of about 59,784 (305)

Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs

Frontiers in Endocrinology, 2022
Glutamate is one of the most abundant amino acids in the blood. Besides its role as a neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a primary messenger that acts through its receptors outside the central nervous ...
Ana Cristina García-Gaytán, Andy Hernández-Abrego, Mauricio Díaz-Muñoz, Isabel Méndez   +3 more
doaj   +1 more source

Shedding Light on Metabotropic Glutamate Receptors [PDF]

Cell Chemical Biology, 2016
In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their ...
openaire   +3 more sources

Membrane Topology of a Metabotropic Glutamate Receptor [PDF]

Journal of Biological Chemistry, 2003
The metabotropic glutamate receptors (mGluRs) have been predicted to have a classical seven transmembrane domain structure similar to that seen for members of the G-protein-coupled receptor (GPCR) superfamily. However, the mGluRs (and other members of the family C GPCRs) show no sequence homology to the rhodopsin-like GPCRs, for which this seven ...
Ruchir D. Shah, D. J. Brasier, Stephen F. Heinemann, Gautam Bhave, Kathi S. Glauner, Robert W. Gereau, Brian M. Nadin, Farzana Karim   +7 more
openaire   +3 more sources

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, Accepted Article.
Controlling protein‐protein interactions is critical for dissecting signaling pathways, especially those initiated by ligand‐receptor interactions which alter receptor oligomerization and drive downstream signaling cascades. Traditional methods for driving protein‐protein complexes are using antibodies that face limitations in terms of stoichiometry ...
Johannes Broichhagen, Michael Trumpp, Blaise Gatin-Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau   +8 more
wiley   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
A. Wade, Berger, Bergeron, Billups, Burlina, Bzdega, Chakraborty, Chatterton, D'Angelo, D. Attwell, Fenwick, Fields, Follett, Jakobs, Jane, K. Kolodziejczyk, Karadottir, Karadottir, Khwaja, Koenig, Kumar, K  rad  ttir, Li, Micu, N. B. Hamilton, Pliss, R. Karadottir, Rubin, Salter, Sartori, Sekiguchi, Tortella, Valivullah, Westbrook, Wevers, Wolf, Wroblewska   +36 more
core   +2 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Neuroadaptations in the Cellular and Postsynaptic Group 1 Metabotropic Glutamate Receptor mGluR5 and Homer Proteins Following Extinction of Cocaine Self-administration [PDF]

, 2009
This study examined the role of group1 metabotropic glutamate receptor mGluR5 and associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration.
Ghasemzadeh, M. Behnam, Mantsch, John R., Mueller, Christopher, Seubert, Chad, Vasudevan, Preethi   +4 more
core   +2 more sources

The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Cell Reports, 2019
Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson, John Georgiou, Patrick Tidball, Graham L. Collingridge   +3 more
doaj  

Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection

Glia, EarlyView.
Toxoplasma infection results in distinct astrocyte subpopulations. Chronically labeled reactive astrocytes appear transcriptionally plastic and can regain acute inflammatory responding and naive homeostatic astrocytic gene patterns in the presence of ongoing neuroinflammation.
Zoe A. Figueroa, Jose L. Martin, Arzu Ulu, William Agnew‐Svoboda, Teresa Ubina, Martin M. Riccomagno, Todd A. Fiacco, Emma H. Wilson   +7 more
wiley   +1 more source

Cross-talk and regulation between glutamate and GABAB receptors

Frontiers in Cellular Neuroscience, 2015
Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
doaj   +1 more source