Results 1 to 10 of about 2,386,092 (307)

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus.

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu   +12 more
doaj   +3 more sources

Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups [PDF]

Brazilian Journal of Otorhinolaryngology, 2019
Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss ...
Sanlin Xie, Jianzhong Li, Wentao Wang, Xianming Chen   +3 more
doaj   +2 more sources

Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

Frontiers in Pharmacology, 2022
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xinying Liu, Le Wang, Le Wang, Jing Ha, Jing Ha, Jing Ha, Zibin Gao, Zibin Gao, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun, Yongjun Sun, Yongjun Sun   +20 more
doaj   +1 more source

Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR

Science, 2023
Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein–coupled receptor, GPR158, as
Thibaut Laboute, S. Zucca, Matthew Holcomb, D. Patil, Chris M Garza, Brittany A. Wheatley, Raktim N. Roy, Stefano Forli, K. Martemyanov   +8 more
semanticscholar   +1 more source

Molecular mechanisms of metabotropic GABAB receptor function

Science Advances, 2021
This review outlines the current understanding of the structure and activation mechanism of the metabotropic GABAB receptors. Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of the two main types of inhibitory ...
H. Shaye, B. Stauch, C. Gati, V. Cherezov   +3 more
semanticscholar   +1 more source

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

Journal of Experimental Medicine, 2021
Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub.
M. Woo, F. Ufer, Nicola Rothammer, Giovanni Di Liberto, Lars Binkle, Undine Haferkamp, J. Sonner, J. B. Engler, S. Hornig, Simone Bauer, Ingrid Wagner, K. Egervari, J. Raber, R. Duvoisin, O. Pless, D. Merkler, M. Friese   +16 more
semanticscholar   +1 more source

Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

eLife, 2021
Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic
Attila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás   +5 more
doaj   +1 more source

Ionotropic and metabotropic responses by alpha 7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of cys-loop receptors characterized by the assembly of five subunits into a multi-protein channel complex.
Patricia Sinclair, Nadine Kabbani
doaj   +1 more source

Brain gamma rhythm and potential treatment of neurodegenerative disease

Journal of Neurorestoratology, 2020
In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz),
Jianhua Zhao, Ailin Du, Chengbiao Lu
doaj   +1 more source

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Nature Communications, 2021
Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activation ...
Anne-Marinette Cao, Robert B. Quast, Fataneh Fatemi, Philippe Rondard, Jean-Philippe Pin, Emmanuel Margeat   +5 more
doaj   +1 more source