Results 1 to 10 of about 2,262,125 (324)

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus. [PDF]

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu   +12 more
doaj   +2 more sources

Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups [PDF]

Brazilian Journal of Otorhinolaryngology, 2019
Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss ...
Sanlin Xie, Jianzhong Li, Wentao Wang, Xianming Chen   +3 more
doaj   +2 more sources

Conformational diversity in class C GPCR positive allosteric modulation [PDF]

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +2 more sources

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer [PDF]

Nature Communications
Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different pharmacology compared to their homodimeric counterparts. Here, we use complemented donor-acceptor resonance energy transfer (CODA-RET) technology that distinguishes
Xin Lin, Davide Provasi, Colleen M. Niswender, Wesley B. Asher, Jonathan A. Javitch   +4 more
doaj   +2 more sources

Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

Frontiers in Pharmacology, 2022
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xinying Liu, Le Wang, Le Wang, Jing Ha, Jing Ha, Jing Ha, Zibin Gao, Zibin Gao, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun, Yongjun Sun, Yongjun Sun   +20 more
doaj   +1 more source

Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR

Science, 2023
Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein–coupled receptor, GPR158, as
Thibaut Laboute, S. Zucca, Matthew Holcomb, D. Patil, Chris M Garza, Brittany A. Wheatley, Raktim N. Roy, Stefano Forli, K. Martemyanov   +8 more
semanticscholar   +1 more source

Molecular mechanisms of metabotropic GABAB receptor function

Science Advances, 2021
This review outlines the current understanding of the structure and activation mechanism of the metabotropic GABAB receptors. Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of the two main types of inhibitory ...
H. Shaye, B. Stauch, C. Gati, V. Cherezov   +3 more
semanticscholar   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

MicroRNA binding site variation is enriched in psychiatric disorders

Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022
Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan, William R. Reay, Murray J. Cairns   +2 more
wiley   +1 more source

Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

eLife, 2021
Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic
Attila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás   +5 more
doaj   +1 more source