Results 1 to 10 of about 2,336,805 (315)
Structures of metabotropic GABAB receptor [PDF]
Nature, 2020 Stimulation of the metabotropic GABAB receptor by γ-aminobutyric acid (GABA) results in prolonged inhibition of neurotransmission, which is central to brain physiology1.
M. Papasergi-Scott +5 more
semanticscholar +7 more sources
Metabotropic glutamate receptor trafficking [PDF]
Molecular and Cellular Neuroscience, 2018 The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh, K. Chang, K. Roche
semanticscholar +4 more sources
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR
Science, 2023 Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein–coupled receptor, GPR158, as
Thibaut Laboute +8 more
semanticscholar +1 more source
Molecular mechanisms of metabotropic GABAB receptor function
Science Advances, 2021 This review outlines the current understanding of the structure and activation mechanism of the metabotropic GABAB receptors. Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of the two main types of inhibitory ...
H. Shaye +3 more
semanticscholar +1 more source
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Journal of Experimental Medicine, 2021 Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub.
M. Woo +16 more
semanticscholar +1 more source
Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen +3 more
openaire +3 more sources
Structural basis of the activation of a metabotropic GABA receptor
Nature, 2020 Metabotropic γ-aminobutyric acid receptors (GABA B ) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis 1 . GABA B belongs to
H. Shaye +9 more
semanticscholar +1 more source
Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia
Molecular Pharmacology, 2022 Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia patients has led to efforts to target various components of glutamatergic signaling as potential new approaches for schizophrenia.
S. Dogra, P. Conn
semanticscholar +1 more source
Metabotropic signaling by kainate receptors [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractKainate receptors (KARs) are members of the ionotropic glutamate receptor family. Despite their ubiquitous presence in the central nervous system, and in contrast to the better characterizedN‐methyl‐d‐aspartates (NMDARs) andα‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors (AMPARs), the contribution of KARs to synaptic ...
Rodrigues, Ricardo J. +1 more
openaire +3 more sources
mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
core +2 more sources