Results 51 to 60 of about 1,802 (157)

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, Volume 25, Issue 21-22, Page 253-276, November 2025.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis

Memorias do Instituto Oswaldo Cruz, 2012
Trypanosomes are parasitic protozoa in which gene expression is primarily controlled through the regulation of mRNA stability and translation. This post-transcriptional control is mediated by various families of RNA-binding proteins, including those with
Patricia Alves Mörking, Rita de Cássia Pontello Rampazzo, Pegine Walrad, Christian Macagnan Probst, Maurilio José Soares, Daniela Fiori Gradia, Daniela Parada Pavoni, Marco Aurélio Krieger, Keith Matthews, Samuel Goldenberg, Stenio Perdigão Fragoso, Bruno Dallagiovanna   +11 more
doaj   +1 more source

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

ChemistrySelect, Volume 10, Issue 37, October 6, 2025.
Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández, Elia Guadalupe Jaimes‐Castelán, Ricardo Reyes‐Chilpa   +2 more
wiley   +1 more source

Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms.

PLoS ONE, 2011
Chagas' disease is a potentially life-threatening illness caused by the unicellular protozoan parasite Trypanosoma cruzi. It is transmitted to humans by triatomine bugs where T. cruzi multiplies and differentiates in the digestive tract.
Renata R Tonelli, Leonardo da Silva Augusto, Beatriz A Castilho, Sergio Schenkman   +3 more
doaj   +1 more source

Host Organelle Interactions Facilitate Cholesterol Acquisition by Trypanosoma cruzi Amastigotes

Journal of Eukaryotic Microbiology, Volume 72, Issue 4, July/August 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease in Latin America. The amastigote, the replicative intracellular form, is essential for infection persistence in vertebrate hosts. These forms exhibit remarkable adaptability, modulating metabolism and growth according to host cell resource availability ...
Carolina de Lima Alcantara, Miria Gomes Pereira, Wanderley de Souza, Narcisa Leal da Cunha‐e‐Silva   +3 more
wiley   +1 more source

Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells.

PLoS ONE, 2010
The complement system is the main arm of the vertebrate innate immune system against pathogen infection. For the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, subverting the complement system and invading the host cells is crucial ...
Igor Cestari, Marcel I Ramirez
doaj   +1 more source

Trypanosoma cruzi: metacyclogenesis in vitro - I. Changes in the properties of metacyclic trypomastigotes maintained in the laboratory by different methods [PDF]

Memórias do Instituto Oswaldo Cruz, 1994
In this work we have studied the modifications in the biological properties of Trypanosoma cruzi when the parasite is maintained for a long time in axenic culture. The studies were done with a clone from an avirulent strain (Dm30L) and a non-cloned virulent strain (EP) of T. cruzi. Both parasites were maintained, for at least three years, by successive
Víctor T. Contreras, Wolfran Araque, Víctor S. Delgado   +2 more
openaire   +4 more sources

Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis

ChemCatChem, Volume 17, Issue 5, March 6, 2025.
This review summarizes the functional, structural, and mechanistic properties of flavin‐dependent nitroreductases and highlights their usefulness for the synthesis of nitrogen‐containing compounds. Recent advances in enzyme and cofactor engineering, as well as in the use of nitroreductases in photobiocatalytic approaches, are emphasized.
Sara Russo, Alejandro Prats Luján, Marco W. Fraaije, Gerrit J. Poelarends   +3 more
wiley   +1 more source

Revisiting the Trypanosoma cruzi metacyclogenesis: morphological and ultrastructural analyses during cell differentiation

Parasites & Vectors, 2018
Background Trypanosoma cruzi uses several strategies to survive in different hosts. A key step in the life-cycle of this parasite is metacyclogenesis, which involves various morphological, biochemical, and genetic changes that induce the differentiation ...
Camila Silva Gonçalves, Andrea Rodrigues Ávila, Wanderley de Souza, Maria Cristina M. Motta, Danielle Pereira Cavalcanti   +4 more
doaj   +1 more source

P21 Ablation Unveils Strain‐Specific Transcriptional Reprogramming in Trypanosoma cruzi Amastigotes

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Trypanosoma cruzi is the causative agent of Chagas disease and is capable of invading any nucleated cell in the vertebrate host. The parasite utilizes various virulence factors during cell invasion, including the P21 protein. P21 is encoded by a single‐copy, nonconserved gene expressed across all T. cruzi life cycle stages.
Anna Clara Azevedo Silveira, Iara Dantas de Souza, João Vitor Ferreira Cavalcante, Thaise Lara Teixeira, Cristina Mary Orikaza, Rodrigo Juliani Siqueira Dalmolin, José Franco da Silveira, Claudio Vieira da Silva, Todd R. Callaway   +8 more
wiley   +1 more source