Results 31 to 40 of about 43,311 (300)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Metadata for the digital preservation of open data: an identification study
Biblios, 2021 Objective. Research that aims to identify useful metadata standards for the preservation and digital availability of open data according to current literature.. Method.
Victória de Abreu e Silva +1 more
doaj +1 more source
Integrating Dublin Core metadata for cultural heritage collections using ontologies [PDF]
, 2007 Metadata interoperability is an active research area, especially for cultural heritage collections, which consist of heterogeneous objects described by a variety of metadata schemas.
Doerr, Martin +6 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Dublin Core Metadata for Electronic Journals [PDF]
, 2000 This paper describes the design of an electronic journals application where the article header information is held as Dublin Core metadata. Current best practice in the use of Dublin Core for bibliographic data description is indicated where this differs
Ann Apps +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Metadata initiatives and emerging technologies to improve resource discovery [PDF]
, 2010 This paper discusses some emerging issues on metadata as a mechanism of resource discovery and its impact on precision of search results in a distributed network environment.
Pal, Jiban K +2 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Towards Standardization: A Participatory Framework for Scientific Standard-Making
International Journal of Digital Curation, 2013 In contemporary scientific research, standard-making and standardization are key processes for the sharing and reuse of data. The goals of this paper are twofold: 1) to stress that collaboration is crucial to standard-making, and 2) to urge recognition ...
Lynn Yarmey, Karen S. Baker
doaj +5 more sources