Results 201 to 210 of about 81,015 (266)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Metagenomic analysis of the biofilm community at the oxic-anoxic interface of a deep-underground saline spring at the Baksan Neutrino Observatory. [PDF]

Microbiol Spectr
Tarasov K, Zarubin M, Yakhnenko A, Gangapshev A, Kravchenko E.   +4 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Comparative metagenomic analysis on COPD and health control samples reveals taxonomic and functional motifs. [PDF]

Front Microbiol
Chen G, Wiegand C, Willett A, Herr C, Müller R, Bals R, Kalinina OV.   +6 more
europepmc   +1 more source

Ecosystem retrogression enhances cross‐domain microbial stability and increases the genetic potential for nutrient cycling

mLife, EarlyView.
Abstract Ecosystem retrogression drives nutrient depletion, reduced productivity, and profound reorganization of soil microbial communities. Using amplicon sequencing and genome‐resolved metagenomics, we examined how cross‐domain microbial networks and functional gene potential respond to long‐term phosphorus and nitrogen limitation along the well ...
Javier A. Ceja‐Navarro, Dishant Patel, Garret Genco, Alyssa Byer, Daliang Ning, Kenneth H. Wan, Susan E. Celniker, Jizhong Zhou, Paul Dijkstra, Bruce A. Hungate, Jennifer Pett‐Ridge, Eoin L. Brodie   +11 more
wiley   +1 more source

Metagenomic analysis revealed the distribution of antibiotic resistance genes of Awang sheep (Ovis aries) gut microbiota. [PDF]

Front Microbiol
Zhao S, Wang X, Zhu H, Guo G, Mustafa GR, Mustafa A, Chen Y, Li X, Wang Y, Zhao B.   +9 more
europepmc   +1 more source

Metagenomic analysis of microbiome spatial dynamics in urban river confluence affected by city wastewater. [PDF]

Genomics Inform
Parwin N, Dixit S, Das S, Sahoo RK, Subudhi E.   +4 more
europepmc   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Metagenomic analysis uncovers novel hepadnaviruses and nackednaviruses. [PDF]

Sci Rep
Ben H, Wang X, Yang P, Li L, Liu P, Gao Y, Wang Y, Liu Y, Huang C, Chen D.   +9 more
europepmc   +1 more source