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Metagenomic Analysis of Tuberculosis in a Mummy

New England Journal of Medicine, 2013
Metagenomic analysis, which involves the sequencing of unenriched DNA from uncultured samples, is probably best known for its use in the analysis of microbes. Here, the method is applied to obtain the sequence of two strains of tuberculosis from a mummified human body.
Jacqueline Z-M, Chan   +8 more
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Metagenome Analysis

2010
The term “metagenomics” represents a combination of molecular and bioinformatic tools used to assess the genetic information of a community without prior cultivation of the individual species. It is valuable for the study of microorganisms of which only a minor fraction is yet culturable.
Meyerdierks, A., Glöckner, F.
openaire   +2 more sources

Pathway-Based Functional Analysis of Metagenomes

Journal of Computational Biology, 2010
Abstract Metagenomic data enables the study of microbes and viruses through their DNA as retrieved directly from the environment in which they live. Functional analysis of metagenomes explores the abundance of gene families, pathways, and systems, rather than their taxonomy.
Itai Sharon   +3 more
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Automation of QIIME2 Metagenomic Analysis Platform

Current Protocols, 2021
AbstractQIIME is a widely used, open‐source microbiome analysis software package that converts raw sequence data into interpretable visualizations and statistical results. QIIME2 has recently succeeded QIIME1, becoming the most updated platform. The protocols in this article describe our effort in automating core functions of QIIME2, using datasets ...
Calvin, Fung   +6 more
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Metagenomic analysis of caseum of tuberculosis foci

Bulletin of Experimental Biology and Medicine
The microbiota of the deep lung regions significantly differs from that of the upper respiratory tract by much lower biomass and dynamic diversity. In our previous studies we found that the biodiversity of the satellite microbiota of tuberculosis foci is sharply reduced in comparison with intact lung tissues.
E A, Orlova   +7 more
openaire   +2 more sources

Diversity Analysis in Viral Metagenomes

2018
Viruses are the most abundant and diverse biological entity in the earth. Nowadays, there are several viral metagenomes from different ecological niches which have been used to characterize new viral particles and to determine their diversity. However, viral metagenomic data have the disadvantage to be high-dimensional compositional and sparse.
openaire   +2 more sources

Workflow for Rapid Metagenome Analysis

2014
Analyses of metagenomes in life sciences present new opportunities as well as challenges to the scientific community and call for advanced computational methods and workflows. The large amount of data collected from samples via next-generation sequencing (NGS) technologies render manual approaches to sequence comparison and annotation unsuitable ...
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In Silico Metagenomics Analysis

2021
The field of metagenomics (study of a system’s microbiome) comes with various questions researchers are called to answer. Questions about the microbiota’s identity, the interactions of the participating bacteria, fungi, and viruses and their associations with health and disease.
openaire   +1 more source

Advances in computational analysis of metagenome sequences

Environmental Microbiology, 2012
Summary Second‐generation sequencing technologies are revolutionizing the study of metagenomes. Whole‐genome shotgun sequencing of metagenomic DNA may become an attractive alternative to the current widely used ribosomal RNA gene studies.
Colin F, Davenport, Burkhard, Tümmler
openaire   +2 more sources

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