Results 141 to 150 of about 58,396 (229)

New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe [PDF]

open access: yes, 2010
The European NDM-1 Survey Participants: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)Acquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat. A novel acquired carbapenemase,
Giesecke, J .   +5 more
core  

Clinical and economic consequences of hospital-acquired resistant and multidrug-resistant Pseudomonas aeruginosa infections: a systematic review and meta-analysis [PDF]

open access: yes, 2014
Background Increasing rates of resistant and multidrug-resistant (MDR) P. aeruginosa in hospitalized patients constitute a major public health threat.
Gavaghan, M.   +4 more
core   +3 more sources

Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.

open access: yesPLoS ONE, 2011
The New Delhi Metallo-β-lactamase (NDM-1) gene makes multiple pathogenic microorganisms resistant to all known β-lactam antibiotics. The rapid emergence of NDM-1 has been linked to mobile plasmids that move between different strains resulting in world ...
Youngchang Kim   +7 more
doaj   +1 more source

Aztreonam Combination Therapy: A Long-Awaited Answer to Metallo-β-Lactamase-Producing Gram-Negatives?

open access: yesClinical Infectious Diseases, 2019
EDITORIAL COMMENTARY • cid 2020:71 (15 August) • 1099 Received 8 November 2019; editorial decision 24 November 2019; accepted 4 December 2019; published online December 5, 2019. Correspondence: Y.
R. Shields, Y. Doi
semanticscholar   +1 more source

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3 [PDF]

open access: yes, 2018
African trypanosomes cause lethal and neglected tropical diseases, known as sleeping sickness in humans and nagana in animals. Current therapies are limited, but fortunately, promising therapies are in advanced clinical and veterinary development ...
Akama   +17 more
core   +3 more sources

Mechanisms of carbapenem resistance in Acinetobacter baumannii [PDF]

open access: yes, 2009
Pripadnici roda Acinetobacter su nefermentativni mikroorganizmi široko rasprostranjeni u vodi i na zemlji. Pojedine vrste unutar roda sastavni su dio fiziološke flore kože i sluznica te su sposobni preživjeti duži vremenski period na suhim i vlažnim ...
Ivana Goić-Barišić
core   +1 more source

The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters.

open access: yesTIPS - Trends in Pharmacological Sciences, 2018
Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze and inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute >50% of the available contemporary antibiotic arsenal. Despite the global
Lincheng Ju   +4 more
semanticscholar   +1 more source

Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM

open access: yesFrontiers in Microbiology
Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xinhui Li   +9 more
doaj   +1 more source

High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China

open access: yesFrontiers in Microbiology, 2019
Enterobacter cloacae has recently emerged as one of the most common carbapenem-resistant Enterobacteriaceae. The emergence and spread of metallo-β-lactamase-producing E. cloacae have posed an immediate threat globally. Here, we investigated the molecular
Yimei Cai   +14 more
semanticscholar   +1 more source

Carbapenemase-producing organisms: a global scourge [PDF]

open access: yes, 2018
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern.
Bonomo, Robert A   +6 more
core  

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