Results 151 to 160 of about 58,396 (229)

Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae

Open Forum Infectious Diseases, 2019
Plazomicin is an aminoglycoside that was approved in June 2018 by the US Food and Drug Administration for the treatment of complicated urinary tract infections, including pyelonephritis, due to Escherichia coli, Klebsiella pneumoniae, Enterobacter ...
A. Serio, T. Keepers, K. Krause
semanticscholar   +1 more source

A STUDY OF METALLO-BETA-LACTATAMASE PRODUCING PSEUDOMONAS AERUGINOSA IN CLINICAL SAMPLES OF S.S.G. HOSPITAL

National Journal of Medical Research, 2011
Introduction: Pseudomonas spp. is common pathogen causing nosocomial infection. Acquired drug resistance is frequent in nosocomial isolates of Pseudomonas spp. Acquired metallo-β-lactamases (MBL) in pseudomonas spp.
Mehul S Chaudhari, Tanuja B Javadekar, Govind Ninama, Govind Ninama, Jivraj Damor   +4 more
doaj  

A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases.

PLoS ONE, 2019
The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their ...
Nazmul H Khan, Anthony A Bui, Yang Xiao, R Bryan Sutton, Robert W Shaw, Benjamin J Wylie, Michael P Latham   +6 more
doaj   +1 more source

The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

Engineering
This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum activity against ...
Zhuoren Ling, Alistair James Macdonald Farley, Aditya Lankapalli, Yanfang Zhang, Shonnette Premchand-Branker, Kate Cook, Andrei Baran, Charlotte Gray-Hammerton, Claudia Orbegozo Rubio, Edgars Suna, Jordan Mathias, Jürgen Brem, Kirsty Sands, Maria Nieto-Rosado, Maria Mykolaivna Trush, Nadira Naznin Rakhi, Willames Martins, Yuqing Zhou, Christopher Joseph Schofield, Timothy Walsh   +19 more
doaj   +1 more source

Molecular Epidemiology of Pseudomonas aeruginosa Isolated from Burn Patients

Armaghane Danesh Bimonthly Journal, 2014
Background & aim: Because of emerging multi-drug resistance (MDR) Pseudomonas aeruginosa strains, treatment of burn patients infected by this bacterium is difficult.
m Anvarinejad, a Japoni, n Rafaatpour, a Alipour, p Abbasi, m Shahidi, j Mardaneh   +6 more
doaj  

Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

Antimicrobial Agents and Chemotherapy, 2009
D. Yong, M. Toleman, C. Giske, Hyun-soo Cho, K. Sundman, Kyungwon Lee, T. Walsh   +6 more
semanticscholar   +1 more source

Resistance to antibiotics in Pseudomonas aeruginosa [PDF]

, 2009
Rezistencija Pseudomonas aeruginosa na antibiotike rezultat je smanjenja propusnosti stanične stijenke, pojačanog efluksa antibiotika iz bakterijske stanice, aktivnosti inaktivirajućih enzima te rjeđe promjene ciljnog mjesta.
Branka Bedenić, Sanda Saredlić
core   +1 more source

New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe [PDF]

, 2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAcquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat.
European NDM-1 Survey Participants, Giesecke, J, Gudlaugsson O, Kristinsson K G, Magiorakos, A P, Monnet, D L, Santos O'Connor, F, Struelens, M J   +7 more
core  

"Golden Era of Antibiotics" - Coming to an end !!!

SRM Journal of Research in Dental Sciences, 2012
Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini, T S Subashini, K S Sridevi Sangeetha, R Shivakumar, Nafeesa Iqbal   +4 more
doaj  

Synergistic combination of ceftazidime and avibactam with Aztreonam against MDR Klebsiella pneumoniae in ICU patients

Scientific Reports
The proliferation of multidrug-resistant, metallo-beta-lactamase-producing Klebsiella pneumoniae (MBL-producing K. pneumoniae) poses a major threat to public health resulting in increasing treatment costs, prolonged hospitalization, and mortality rate ...
Sally Khattab, Aya Mohamed Askar, Hidi A. A. Abdellatif, Amira A. A. Othman, Amal H. Rayan, Hasnaa Azab   +5 more
doaj   +1 more source