Results 221 to 229 of about 58,396 (229)

Activity of aztreonam in combination with novel β-lactamase inhibitors against metallo-β-lactamase-producing Enterobacterales from Spain.

International Journal of Antimicrobial Agents, 2023
Metallo-β-lactamase (MBL)-producing Enterobacterales are of particular concern because they are widely disseminated and difficult to treat, being resistant to almost all β-lactam antibiotics.
J. C. Vázquez-Ucha, Isaac Alonso-García, Paula Guijarro-Sánchez, Cristina Lasarte-Monterrubio, L. Álvarez-Fraga, Arnau Cendón-Esteve, Michelle Outeda, Romina Maceiras, Andrea Peña-Escolano, M. Martínez-Guitián, J. Arca-Suárez, G. Bou, A. Beceiro   +12 more
semanticscholar   +1 more source

The present danger of New Delhi metallo-β-lactamase: a threat to public health.

Future Microbiology, 2021
The evolution of antimicrobial-resistant Gram-negative pathogens is a substantial menace to public health sectors, notably in developing countries because of the scarcity of healthcare facilities.
Muhammad Usman Qamar, Bruno S Lopes, B. Hassan, M. Khurshid, M. Shafique, Muhammad Atif Nisar, M. Mohsin, Z. Nawaz, S. Muzammil, B. Aslam, H. Ejaz, Mark A Toleman   +11 more
semanticscholar   +1 more source

Metallo-β-lactamase inhibitors: A continuing challenge for combating antibiotic resistance.

Biophysical Chemistry
β-lactam antibiotics are the most successful and commonly used antibacterial agents, but the emergence of resistance to these drugs has become a global health threat.
Su-Jin Kang, Do-Hee Kim, Bong-Jin Lee
semanticscholar   +1 more source

Activity of aztreonam in combination with ceftazidime-avibactam against serine- and metallo-β-lactamase-producing Pseudomonas aeruginosa.

Diagnostic microbiology and infectious disease, 2020
Existing data support the combination of aztreonam and ceftazidime-avibactam against serine-β-lactamase (SBL)- and metallo-β-lactamase (MBL)-producing Enterobacterales, although there is a paucity of data against SBL- and MBL-producing Pseudomonas ...
Michelle Lee, Taylor C. Abbey, M. Biagi, E. Wenzler   +3 more
semanticscholar   +1 more source

ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae.

ACS Infectious Diseases, 2020
The clinical effectiveness of the important β-lactam class of antibiotics is under threat by the emergence of resistance, mostly due to the production of acquired serine- (SBL) and metallo-β-lactamase (MBL) enzymes.
D. Davies, Simon Leiris, N. Sprynski, J. Castandet, C. Lozano, J. Bousquet, M. Zalacain, Srinivas Vasa, P. Dasari, Ramesh Pattipati, Naresh Vempala, Swetha Gujjewar, Syamkumar Godi, Raju Jallala, Rajashekar Sathyap, N. Darshanoju, V. Ravu, R. R. Juventhala, Narender Pottabathini, Somesh Sharma, S. Pothukanuri, Kirsty Holden, P. Warn, Francesca Marcoccia, M. Benvenuti, C. Pozzi, S. Mangani, J. Docquier, M. Lemonnier, M. Everett   +29 more
semanticscholar   +1 more source

Principles and current strategies targeting metallo-β-lactamase mediated antibacterial resistance.

Medicinal research reviews (Print), 2020
Resistance to β-lactam antibacterials is commonly associated with the production of the serine β-lactamases (SBLs) and/or metallo-β-lactamases (MBLs). Although clinically useful inhibitors for the SBLs have been developed, no equivalent inhibitors are ...
Yu-Hang Yan, Gen Li, Guo-Bo Li
semanticscholar   +1 more source

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Nature Chemistry, 2021
J. Brem, Tharindi D Panduwawala, J. Hansen, J. Hewitt, E. Liepiņš, Pawel Donets, L. Espina, Alistair J. M. Farley, K. Shubin, Gonzalo Gomez Campillos, P. Kiuru, S. Shishodia, D. Krahn, Robert K. Leśniak, Juliane Schmidt (Adrian), Karina Calvopiña, M. Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, P. Hinchliffe, G. Langley, A. Aboklaish, A. Eneroth, M. Backlund, A. Baran, E. Nielsen, M. Speake, J. Kuka, John Robinson, S. Grinberga, Lindsay Robinson, M. McDonough, Anna M. Rydzik, T. Leissing, Juan-Carlos Jiménez-Castellanos, M. Avison, Solange Da Silva Pinto, A. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, M. Gniadkowski, A. Belfrage, P. Brandt, J. Yli-Kauhaluoma, E. Bacqué, M. Page, F. Björkling, J. Tyrrell, J. Spencer, P. Lang, P. Baranczewski, R. Cantón, Stuart P. McElroy, Philip S. Jones, F. Baquero, E. Suna, A. Morrison, T. Walsh, C. Schofield   +60 more
semanticscholar   +1 more source

Ceftazidime-avibactam, meropenen-vaborbactam, and imipenem-relebactam in combination with aztreonam against multidrug-resistant, metallo-β-lactamase-producing Klebsiella pneumoniae

European Journal of Clinical Microbiology and Infectious Diseases, 2021
S. Maraki, V. Mavromanolaki, P. Moraitis, D. Stafylaki, Anna Kasimati, Eleni Magkafouraki, E. Scoulica   +6 more
semanticscholar   +1 more source