Results 101 to 110 of about 24,294 (246)

MODERN OSTEOARTHRITIS THERAPY: ALFLUTOP IN CLINICAL PRACTICE, EXPERIMENTAL AND CLINICAL DATA

Медицинский совет, 2017
The article discusses experimental data that demonstrated the ability of Aflutop to stimulate proliferation and regeneration of chondrocytes, to inhibate in vitro extracellular release of IL-6 cytokine and IL-8 chemokine compared to control cells, to ...
N. V. Chichasova
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]

, 2002
The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Beer, N., Dodt, J., Etscheid, M., Fink, E., Seitz, R.   +4 more
core   +1 more source

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, EarlyView.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Decellularized diaphragmatic muscle drives a constructive angiogenic response in vivo [PDF]

, 2018
Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and acquired defects. Biological acellular scaffolds are considered a good tool for TE, as decellularization allows structural preservation of tissue extracellular matrix
Alvar\ue8z Fallas, Mario, Bertin, Enrica, Burns, Alan, De Coppi, Paolo, Dedja, Arben, Franzin, Chiara, Gamba, Piergiorgio, Piccoli, Martina, Pozzobon, Michela, Sgr\uf2, Alberto, Trevisan, Caterina, Urbani, Luca   +11 more
core   +4 more sources

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Expression of avian prickle genes during early development and organogenesis [PDF]

, 2008
Chicken homologues of prickle-1 (pk-1) and prickle-2 (pk-2) were isolated to gain insight into the extent of planar cell polarity signaling during avian embryogenesis.
Carreira-Barbosa, Chan, Classen, Cooper, Crompton, Dawid, Deans, Desnoyers, Drusco, Fanto, Formstone, Fraser, Gibson, Gros, Gubb, Hamburger, Jiang, Jones, Kadrmas, Katoh, Lawrence, Lecuit, Maurer-Stroh, Michelsen, Münsterberg, Porter, Rath, Schmidt, Seifert, Shimada, Shimojo, Shimojo, Slusarski, Smith, Somerville, Sproul, Strutt, Tsuda, Veeman, Xue, Zhou   +40 more
core   +1 more source

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, EarlyView.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis

Memorias do Instituto Oswaldo Cruz
BACKGROUND Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host’s defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in
Amanda Sutter, Deborah Antunes, Mariana Silva-Almeida, Maurício Garcia de Souza Costa, Ernesto Raul Caffarena   +4 more
doaj   +1 more source

Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes [PDF]

, 2017
The microgravitational environment is known to affect the cellular behaviour inducing modulation of gene expression and enzymatic activities, epigenetic modifications and alterations of the structural organization. Simulated microgravity, obtained in the
Bizzarri, Mariano, Catizone, Angiolina, Cucina, Alessandra, Dinicola, Simona, Masiello, Maria Grazia, Proietti, Sara, Ranieri, Danilo, Ricci, Giulia, Rosato, Benedetta, Torrisi, Maria Rosaria   +9 more
core   +1 more source