Results 91 to 100 of about 32,111 (260)
Biomarkers to predict outcomes in diabetic foot ulcers
VIEW, EarlyView.Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro +6 more
wiley +1 more source
Article Do Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics? [PDF]
, 2015 : An imbalance between matrix metalloproteases (MMPs) and the tissue inhibitors of metalloproteases (TIMPs) may have a negative impact on the healing of rotator cuff tears. The aim of the project was to assess a possible relationship between clinical and
Klatte-Schulz, Franka +13 more
core +1 more source
MODERN OSTEOARTHRITIS THERAPY: ALFLUTOP IN CLINICAL PRACTICE, EXPERIMENTAL AND CLINICAL DATA
Медицинский совет, 2017 The article discusses experimental data that demonstrated the ability of Aflutop to stimulate proliferation and regeneration of chondrocytes, to inhibate in vitro extracellular release of IL-6 cytokine and IL-8 chemokine compared to control cells, to ...
N. V. Chichasova
doaj +1 more source
Microbiology and Immunology, EarlyView.ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi +3 more
wiley +1 more source
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases [PDF]
, 2017 Thiolutin is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Its biological targets are not known. We show that reduced thiolutin is a zinc chelator that inhibits the JAB1/MPN/Mov34 (JAMM) domain-containing ...
Wever, Walter J +43 more
core +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Background Pelvic organ prolapse (POP) affects up to 50% of postmenopausal women, negatively impacting sexual function and quality of life. While surgery remains the primary treatment, increasing attention has been given to perioperative vaginal oestrogen therapy and its potential impact on surgical outcomes.
Gilda Sicilia +7 more
wiley +1 more source
Cartilage metalloproteases in disuse atrophy [PDF]
, 1995 A canine knee model of disuse atrophy produced by nonrigid fixation (sling) was characterized in respect to variables of proteoglycan size distribution, as well as biomechanical properties versus controls.
Setton, L A +8 more
core
Australian Veterinary Journal, EarlyView.Objective To report 45 cases of melioidosis in dogs and cats from northern Australia and analyse trends in epidemiology, clinical presentation, pathogenesis and response to treatment over a 27‐year period. Design Retrospective and prospective analysis of clinical records.
K Lee +6 more
wiley +1 more source
Memorias do Instituto Oswaldo CruzBACKGROUND Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host’s defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in
Amanda Sutter +4 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source