Results 71 to 80 of about 32,111 (260)
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source
Metal Preferences of Zinc-Binding Motif on Metalloproteases [PDF]
, 2011 Almost all naturally occurring metalloproteases are monozinc enzymes. The zinc in any number of zinc metalloproteases has been substituted by some other divalent cation.
Fukasawa, Kayoko M +11 more
core +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi +1 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
Inhibitory activity of galardin and compound 1b against human and bacterial metalloproteases. [PDF]
, 2018 Inhibitory activity of galardin and compound 1b against human and bacterial metalloproteases.
Eli Berg (350448) +9 more
core +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Catalytic mechanism for thermolysin by improved kinetic assay for metalloproteases. [PDF]
, 2002 Catalytic mechanism for thermolysin by improved kinetic assay for ...
Daniel Joseph. Stanford (7975982)
core
Developing Photoactive Affinity Probes for Proteomic Profiling: Hydroxamate-based Probes for Metalloproteases [PDF]
, 2016 The denaturing aspect of current activity-based protein profiling strategies limits the classes of chemical probes to those which irreversibly and covalently modify their targeting enzymes.
Souvik Chattopadhaya (651379) +4 more
core +1 more source
Epithelial – Mesenchymal Interactions in Tooth Development and the Significant Role of Growth Factors and Genes with Emphasis on Mesenchyme – A Review [PDF]
Journal of Clinical and Diagnostic Research, 2016 The recent advancements in medical research field mainly highlights the genetic and molecular aspects of various disease processes and related treatment options, in a specialized “custom-made” approach.
JAYA SEKHARAN VANNADIL PUTHIYAVEETIL +4 more
doaj +1 more source
Metalloproteases and Adipogenesis: A Weighty Subject [PDF]
The American Journal of Pathology, 2002 Obesity has become a prevalent health hazard in industrialized countries and is closely associated with a number of pathological disorders such as cancer, cardiovascular disease, hypertension, and non-insulin-dependent diabetes. 1 Even with such serious health implications there is still a great deal to learn before we can fully understand the ...
Jennifer, Lilla +2 more
openaire +2 more sources