Results 131 to 140 of about 32,111 (260)

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source

Metalloproteases as potential therapeutic targets in arthritis treatment [PDF]

Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy has been elusive.
Rowan AD, Milner JM, Litherland GJ, Hui W   +3 more
core  

[Hepatic fibrosis: role of matrix metalloproteases and TGFbeta] [PDF]

, 2005
Liver fibrosis and cirrhosis involve multiple cellular and molecular events that lead to deposition of an excess of extracellular matrix proteins and increase the distortion of normal liver architecture.
Galvez-Gastelum FJ, Meza-García E, Senties-Gomez MD, Armendariz-Borunda J   +3 more
core   +2 more sources

Low Rate of Postoperative Pterygium Recurrence in Patients under Treatment with Low-Dose Oral Doxycycline for Chronic Blepharitis: A First Report

Diagnostics
Purpose: Low doses of systemic doxycycline (LD-SD) inhibit angiogenesis and the expression of matrix metalloproteases, which are determinants of pterygium progression.
Fiammetta Catania, Paolo Vinciguerra, Alessandra Di Maria   +2 more
doaj   +1 more source

Histopathological investigation of wound healing activities of Lucilia sericata Larva and Achillea sintenisii extract combinations in diabetic rat wound model

Medical and Veterinary Entomology, EarlyView.
Lucilia sericata larvae secrete bioactive compounds that promote wound debridement and antimicrobial defence in chronic tissue injuries. Achillea sintenisii extract offers phytotherapeutic support, enhancing healing through anti‐inflammatory and regenerative properties. Diabetic Wistar rats were treated topically with Furacin®, larval secretions, plant
Nevra Polat, Salih Mollahaliloğlu, Murat Koç   +2 more
wiley   +1 more source

Aryl-sulphonamidic dimers as metalloproteases inhibitors [PDF]

, 2010
The invention is related to the prepn. of title compds. M-L-M' [M, M' = independently the residues of metalloproteases inhibitors of formula RS(O)nNR1CR2R3G; R = -Ar-X-Ar'; Ar = (un)substituted (hetero)arylene; Ar' = H, (un)substituted (hetero)aryl; X ...
ROSSELLO, ARMANDO, ORLANDINI, ELISABETTA, NUTI, ELISA, TUCCINARDI, TIZIANO   +3 more
core  

The evolutionary origins of streptophyte multicellularity

New Phytologist, EarlyView.
The phylogeny of streptophytes and the deep origin of branching filamentous growth. Summary Over their more than 1 billion years of evolutionary history, streptophytes have repeatedly transitioned between unicellular, simple multicellular and complex multicellular forms.
Tatyana Darienko, Cäcilia F. Kunz, Elisa S. Goldbecker, Erika Endriulaitytė, Maaike J. Bierenbroodspot, Maike Lorenz, Iker Irisarri, Thomas Pröschold, Katharina Bürstenbinder, Henrik Buschmann, Jan de Vries   +10 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Altered extracellular matrix remodeling accompanies decreased lncRNA HOTAIR expression in Takayasu arteritis

Frontiers in Immunology
ObjectivesTakayasu arteritis (TAK) is a large-vessel vasculitis characterized by chronic vascular inflammation and extracellular matrix (ECM) remodeling.
Fernanda Espinosa-Bautista, María G. Soberanes-García, Diana Castillo-Martínez, Rashidi Springall, Adrián Hernández-Díazcouder, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra   +7 more
doaj   +1 more source