Results 151 to 160 of about 32,111 (260)

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, Volume 269, Issue 4-5, Page 433-445, August 2026.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Evolution of N‐terminal mechanical lability as a determinant for Type III secretion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
Katherine E. DaPron, Alexandre M. Plastow, Morgan R. Fink, Brandon Dzuba, Marc‐Andre LeBlanc, Thomas T. Perkins, Emad Tajkhorshid, Marcelo C. Sousa   +7 more
wiley   +1 more source

Infectivity of amphibian chytrid fungi requires metalloprotease-driven spore development and germ tube formation. [PDF]

BMC Microbiol
Verbrugghe E, Pasmans F, Martel A.
europepmc   +1 more source

Integrative Identification of Anti‐Photoaging Peptides From Stress‐Tolerant Microorganisms via Machine Learning and KEAP1–NRF2 Docking

Journal of Peptide Science, Volume 32, Issue 8, August 2026.
Novel short‐chain peptides targeting the KEAP1‐NRF2 axis were identified through a multimodal discovery platform combining a stress‐tolerant microbial library with machine learning and molecular docking. These peptides regulate collagen synthesis and reduce MMP1/9 levels in human fibroblasts, providing significant protection against photoaging ...
Hanui Lee, Gyeong Han Jeong, Ji Wan Choi, Taehwan Kim, Younhee Shin, Jaewon Lim, Kwang‐Woo Jung, Byung Yeoup Chung, Seung Sik Lee   +8 more
wiley   +1 more source

Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms. [PDF]

Toxins (Basel)
Khatibi M, Almeida JR, Gilabadi S, Ramírez D, Valenzuela-Hormazábal P, Patel K, Vaiyapuri S.   +6 more
europepmc   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Microbial proteases and endothelial barrier disruption in sepsis: A neglected nexus. [PDF]

Virulence
Rao SS, Shenoy M S, Gutti RK, Prabhu V, Joshi M, Nayak UY, Bharath Prasad AS.   +6 more
europepmc   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Proximity-Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases. [PDF]

Angew Chem Int Ed Engl
Berthy L, Pasco U, Sejalon-Cipolla M, Bruyat P, Kaminska M, Malgorn C, Beau F, Osolin M, Novak M, Breznik B, Georgiadis D, Correia I, Groult E, Lequin O, Bregant S, Pers YM, Noel D, Thai R, Subra G, Cantel S, Devel L.   +20 more
europepmc   +1 more source

Monocyte Single‐Cell‐Type Gene Expression Analysis Differentiates Kawasaki Disease From Viral Infection With High Specificity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Kawasaki disease (KD) and viral infection (VD) share similar clinical features but require distinct treatments. A practical biomarker to distinguish them is therefore clinically important. Previous blood transcriptome studies identified many differentially expressed genes, but large gene panels are impractical for routine laboratories. A ratio‐
Nelson L. S. Tang, Tsz‐Ki Kwan, Assunta C. H. Ho, Hugh Simon Lam, Geoffrey Mok, Dan Huang, Suk‐Ling Ma, Kwong‐Sak Leung   +7 more
wiley   +1 more source