Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry [PDF]
, 2002 Nano-electrospray ionization time-of-flight mass spectrometry (ESI-MS) was used to study the conformational consequences of metal ion binding to the colicin E9 endonuclease (E9 DNase) by taking advantage of the unique capability of ESI-MS to allow ...
HECK, ALBERT J.R. +6 more
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Machine learning differentiates enzymatic and non-enzymatic metals in proteins
Nature Communications, 2021 The authors generate the largest structural dataset of enzymatic and non-enzymatic metalloprotein sites to date. They use this dataset to train a decision-tree ensemble machine learning algorithm that allows them to distinguish between catalytic and non ...
Ryan Feehan +2 more
doaj +1 more source
NMR Studies of Metalloproteins [PDF]
, 2011 Metalloproteins represent a large share of the proteomes, with the intrinsic metal ions providing catalytic, regulatory, and structural roles critical to protein functions. Structural characterization of metalloproteins and identification of metal coordination features including numbers and types of ligands and metal-ligand geometry, and mapping the ...
Sun, H, Li, H
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Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
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Frontiers in Plant Science, 2018 Iron-sulfur (Fe-S) clusters are evolutionarily ancient ubiquitous protein cofactors which have mostly catalytic functions but can also have structural roles.
Hongliang Zhang, Ute Krämer
doaj +1 more source
Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients. [PDF]
PLoS ONE, 2015 Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the ...
Michael Syka +7 more
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Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in
mBio, 2019 Respiration is a fundamental process that has to optimally respond to metabolic demand and environmental changes. We previously showed that nitrate respiration, crucial for gut colonization by enterobacteria, is controlled by polar clustering of the ...
Suzy Bulot +8 more
doaj +1 more source
Renormalization of myoglobin-ligand binding energetics by quantum many-body effects [PDF]
, 2014 We carry out a first-principles atomistic study of the electronic mechanisms of ligand binding and discrimination in the myoglobin protein. Electronic correlation effects are taken into account using one of the most advanced methods currently available ...
Cole, Daniel J. +3 more
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A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]
, 2007 Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski +48 more
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Is the olfactory receptor a metalloprotein? [PDF]
Proceedings of the National Academy of Sciences, 2003 The sense of smell is arguably our most primal faculty and also the least understood. Even our own olfactorily impaired species is capable of detecting ≈10,000 distinct scents [Buck, L. & Axel, R. (1991)Cell65, 175–187]. To achieve that amazing diversity, mammals have ≈1,000 olfactory genes, which accounts for ≈3% of their entire genome [Mombaerts,
Zaida Luthey-Schulten +2 more
openaire +3 more sources