Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients. [PDF]
PLoS ONE, 2015 Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the ...
Michael Syka +7 more
doaj +1 more source
Metallomics in environmental and health related research: Current status and perspectives [PDF]
, 2013 Metals and metalloids play distinct roles in human health, either beneficial or toxic, depending on their concentrations and species. There is an increasing interest in metals uptake, trafficking, function, and exertion in microorganisms to maintain and ...
G.B., J, He, B, Hu, L, Sun, H, Wang, Y
core +1 more source
Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in
mBio, 2019 Respiration is a fundamental process that has to optimally respond to metabolic demand and environmental changes. We previously showed that nitrate respiration, crucial for gut colonization by enterobacteria, is controlled by polar clustering of the ...
Suzy Bulot +8 more
doaj +1 more source
Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]
, 2015 Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S +6 more
core +1 more source
Human CTR1 Through the Ages: Milestones and Emerging Roles in Disease and Therapy
BiomoleculesCopper transporter 1 (CTR1) is the primary high affinity importer for Cu(I) in eukaryotic cells. CTR1 plays an essential role in maintaining copper homeostasis which is crucial for diverse biological processes.
Shahaf Peleg +2 more
doaj +1 more source
Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial [PDF]
, 2005 In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment ...
Friess, Wolfgang +6 more
core +1 more source
Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold
European Journal of Inorganic Chemistry, EarlyView.A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy +3 more
wiley +1 more source
Absolute Configuration Determination with Electronically Enhanced Vibrational Circular Dichroism
Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.We introduce a practical workflow for simulating vibrational circular dichroism spectra enhanced by vibronic coupling. We achieve qualitative agreement with experiment for Co(II) and Ni(II) spartein complexes, circumventing inaccuracies in theoretical excitation energy predictions.
Mariia Sapova +4 more
wiley +2 more sources
Frontiers in Plant Science, 2018 Iron-sulfur (Fe-S) clusters are evolutionarily ancient ubiquitous protein cofactors which have mostly catalytic functions but can also have structural roles.
Hongliang Zhang, Ute Krämer
doaj +1 more source
Two-stage binding of mitochondrial ferredoxin-2 to the core iron-sulfur cluster assembly complex
Nature CommunicationsIron-sulfur (FeS) protein biogenesis in eukaryotes begins with the de novo assembly of [2Fe-2S] clusters by the mitochondrial core iron-sulfur cluster assembly (ISC) complex.
Ralf Steinhilper +7 more
doaj +1 more source