Results 271 to 280 of about 218,326 (315)
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Current Opinion in Chemical Biology, 1998
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
Summary 1. Crystalline agavain has been shown to be inhibited by metal binding agents and DFP, but not by sulfhydryl reagents. 2. The activity of agavain is sensitive to the nature of the buffer solution used in the assay medium, this inhibitory effect being a function of the buffer anions. 3.
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Summary 1. Crystalline agavain has been shown to be inhibited by metal binding agents and DFP, but not by sulfhydryl reagents. 2. The activity of agavain is sensitive to the nature of the buffer solution used in the assay medium, this inhibitory effect being a function of the buffer anions. 3.
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Measurement of Metalloproteinases
2003Matrix metalloproteinases (MMPs) (1,2) comprise a family of over 20 matrix degrading enzymes believed to be essential for normal development and physiologic tissue remodeling and repair. Abnormal expression of metalloproteinases has been implicated in many destructive processes, including tumor cell invasion and angiogenesis, arthritis, atherosclerosis,
S D, Shapiro, D, Kelley, D, Kobayashi
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2012
Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many ...
Viola, Vargová +2 more
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Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many ...
Viola, Vargová +2 more
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Structural Basis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
Molecular Biotechnology, 2003The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all of which exhibit a catalytic domain of a common metzincin-like topology, and which are involved in degradation of the extracellular matrix but also in a number of other biologic processes. Normally, the proteolytic activity of
Maskos, K., Bode, W.
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function
Reviews of Reproduction, 1998Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the ...
E W, McIntush, M F, Smith
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas
Journal of Neurosurgery, 1995✓ The gene expression of five matrix metalloproteinases (MMPs) and two tissue inhibitors of metalloproteinases (TIMPs) was studied in human gliomasin vivoandin vitroto evaluate their roles in glioma invasion. Simultaneous expression of one to four MMP genes and two TIMP genes was found in 17 surgical glioma specimens, and one MMP (gelatinase A) gene ...
A, Nakano +4 more
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Characterization of Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Plasma
Connective Tissue Research, 1992In this study, we have identified and characterized metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) in human plasma. Treatment of plasma with trypsin or aminophenylmercuric acetate resulted in activation of latent gelatinolytic activity.
D, Moutsiakis +4 more
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Metalloproteinases and their inhibitors in angiogenesis
Expert Reviews in Molecular Medicine, 2003Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being crucial for the growth of solid ...
Lafleur, M.A. +2 more
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Matrix metalloproteinases and atherosclerosis
Current Atherosclerosis Reports, 2004Atherosclerosis is a major cause of coronary heart disease, and matrix metalloproteinases (MMPs) play an important role in atherosclerosis by degrading the extracellular matrix, which results in cardiovascular remodeling. Recent studies have identified enhanced expression of MMPs in the atherosclerotic lesion and their contribution to weakening of the ...
Noboru, Watanabe, Uichi, Ikeda
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