Results 281 to 290 of about 218,326 (315)
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The Matrix Metalloproteinases and Their Inhibitors
American Journal of Respiratory Cell and Molecular Biology, 1992Abstract A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been ...
G, Murphy, A J, Docherty
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Matrix metalloproteinases and metastasis
Cancer Chemotherapy and Pharmacology, 1999Metastatic disease is responsible for the majority of cancer-related deaths, either directly due to tumor involvement of critical organs or indirectly due to complications of therapy to control tumor growth and spread. An understanding of the mechanisms of tumor cell invasion and metastasis may be important for devising therapies aimed at preventing ...
D E, Kleiner, W G, Stetler-Stevenson
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Matrix metalloproteinase inhibitors
Investigational New Drugs, 1997The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all of the components of the extracellular matrix, including fibrallar and non-fibrallar collagens, fibronectin, laminin and basement membrane glycoproteins.
S M, Wojtowicz-Praga +2 more
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Platelets and matrix metalloproteinases
Thrombosis and Haemostasis, 2013SummaryMatrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes.
P, Seizer, A E, May
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Matrix metalloproteinases in immunity
The Journal of Immunology, 1996Abstract Matrix metalloproteinases (MMPs) are a family of zinc-containing endo-proteinases that share structural domains but differ in substrate specificity, cellular sources, and inducibility. Macrophage production and secretion of large quantities of many MMPs, after contact with matrix proteins, is enhanced by surface determinants ...
E J, Goetzl, M J, Banda, D, Leppert
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Seminars in Oncology, 2002Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
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Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium
Arthritis & Rheumatism, 1991AbstractThe expression of messenger RNA encoding neutral metalloproteinases and the tissue inhibitor of metalloproteinases (TIMP) in human arthritic synovium was evaluated in situ, using RNA probes. Interstitial collagenase and stromelysin were expressed by synovial lining cells in patients with active rheumatoid arthritis (RA).
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Metalloproteinase Changes in Diabetes
2016Matrix metalloproteinases (MMPs) constitute a group of over 20 structurally-related proteins which include a Zn(++) ion binding site that is essential for their proteolytic activities. These enzymes play important role in extracellular matrix turnover in order to maintain a proper balance in its synthesis and degradation. MMPs are associated to several
Bento João, Abreu +1 more
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Matrix metalloproteinases in repair
Wound Repair and Regeneration, 1999During repair, many different matrix metalloproteinases are produced by multiple cell types residing in various compartments within the wound environment. This diversity of enzymes, coupled with discreet cellular expression, implies that different matrix metalloproteinases serve different functions, acting on a variety of substrates, during wound ...
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