Results 21 to 30 of about 22,892 (210)

Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity [PDF]

, 2012
In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes.
Gao, Zhiwei, Hu, Jinyu
core   +3 more sources

Bioinformatic Mapping of Opine-Like Zincophore Biosynthesis in Bacteria

mSystems, 2020
Zinc is an essential nutrient in biological systems due to its structural or catalytic requirement in proteins involved in diverse cellular processes. To meet this cellular demand, microbes must acquire sufficient zinc from their environment.
Jacqueline R. Morey, Thomas E. Kehl-Fie
doaj   +1 more source

Assessing the prospect of XAFS experiments of metalloproteins under in vivo conditions at Indus-2 synchrotron facility, India

Journal of Synchrotron Radiation, 2023
The feasibility of X-ray absorption fine-structure (XAFS) experiments of ultra-dilute metalloproteins under in vivo conditions (T = 300 K, pH = 7) at the BL-9 bending-magnet beamline (Indus-2) is reported, using as an example analogous synthetic Zn (0.1 ...
Debdutta Lahiri, Richa Agrawal, Khileshwari Chandravanshi, Parasmani Rajput, Ankur Agrawal, Ashutosh Dwivedi, Ravindra D. Makde, S. N. Jha, Nandini Garg   +8 more
doaj   +1 more source

Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin [PDF]

, 2007
Understanding how the folding of proteins establishes their functional characteristics at the molecular level challenges both theorists and experimentalists.
Adman, Bryngelson, Bryngelson, C. J. Wilson, C. Zong, Crane, Frauenfelder, Gray, Malmstrom, Marks, Matouschek, Matouschek, Miyazawa, Nar, Nar, Onuchic, P. G. Wolynes, P. Wittung-Stafshede, Pozdnyakova, Ryde, S. L. Mayo, Solomon, T. Shen, Vallee, Williams, Winkler   +25 more
core   +3 more sources

Quantitative Preparative Native Continuous Polyacrylamide Gel Electrophoresis (QPNC-PAGE) [PDF]

, 2008
QPNC-PAGE, or quantitative preparative native continuous polyacrylamide gel electrophoresis, is a high-resolution technique applied in biochemistry and bioinorganic chemistry to separate proteins by isoelectric point.
Bernd Kastenholz
core   +2 more sources

How Theoretical Evaluations Can Generate Guidelines for Designing/Engineering Metalloproteins with Desired Metal Affinity and Selectivity

Molecules, 2022
Almost half of all known proteins contain metal co-factors. Crucial for the flawless performance of a metalloprotein is the selection with high fidelity of the cognate metal cation from the surrounding biological fluids.
Todor Dudev
doaj   +1 more source

NMR studies of metalloproteins [PDF]

, 2011
Metalloproteins represent a large share of the proteomes, with the intrinsic metal ions providing catalytic, regulatory, and structural roles critical to protein functions.
Li, H, Sun, H
core   +1 more source

Towards the spatial resolution of metalloprotein charge states by detailed modeling of XFEL crystallographic diffraction. [PDF]

, 2020
Oxidation states of individual metal atoms within a metalloprotein can be assigned by examining X-ray absorption edges, which shift to higher energy for progressively more positive valence numbers.
Holton, James M, Kern, Jan, Sauter, Nicholas K, Yano, Junko   +3 more
core   +2 more sources

Metalloproteins in the Biology of Heterocysts

Life, 2019
Cyanobacteria are photoautotrophic microorganisms present in almost all ecologically niches on Earth. They exist as single-cell or filamentous forms and the latter often contain specialized cells for N2 fixation known as heterocysts.
Rafael Pernil, Enrico Schleiff
doaj   +1 more source

The Stereochemical Basis of the Genetic Code and the (Mostly) Autotrophic Origin of Life

Life, 2014
Spark-tube experiments and analysis of meteorite contents have led to the widespread notion that abiotic organic molecules were the first life components.
Juan C. Fontecilla-Camps
doaj   +1 more source