Results 1 to 10 of about 77,240 (295)
Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications [PDF]
AntioxidantsMetallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
Ruoqiu Yang +4 more
doaj +3 more sources
Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain
Journal of Neuroinflammation, 2021 Background We previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that MT2 within the spinal dorsal horns participates in the development of oxaliplatin-
Xuelin Huang +5 more
doaj +2 more sources
Anti-metallothionein IgG and levels of metallothionein in autistic families [PDF]
Swiss Medical Weekly, 2008 Metallothioneins (MTs) are a family of small proteins containing 61-68 amino acids with an unusually high concentration of cysteine. MT-1, the most functional and active MT in humans, has the ability to react with and enhance the detoxification of a number of metals including zinc, mercury, copper and cadmium.
A Russo
doaj +3 more sources
Structure of Mammalian Metallothionein [PDF]
Environmental Health Perspectives, 1984 All mammalian metallothioneins characterized contain a single polypeptide chain of 61 amino acid residues, among them 20 cysteines providing the ligands for seven metal-binding sites. Native metallothioneins are usually heterogeneous in metal composition, with Zn, Cd, and Cu occurring in varying proportions.
David E. O. Gilg +6 more
openaire +4 more sources
Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts [PDF]
, 2009 In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process.
Boilan, Emmanuelle +9 more
core +23 more sources
Metallothionein Protein Modeling from Pseudomonas aeruginosa PAO1 as A Metal Biosorber Candidate
Jurnal Biodjati, 2023 Metallothionein is a protein that is well known to play a role in metal metabolism in bacterial cells. Metallothionein is a multifunctional protein that has the potential to be used as a metal adsorbing agent.
Fajri Ikhsan +2 more
doaj +1 more source
Depik Jurnal, 2022 This research was conducted in October 2021 using a survey method. Sampling was carried out three times with a span of every 2 weeks at 3 stations along the lower reaches of the Welang River Pasuruan Regency.
Lisma Wardani +2 more
doaj +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
IUBMB Life, 2017 AbstractMetallothioneins (MTs) are a class of low molecular weight and cysteine‐rich metal binding proteins present in all the branches of the tree of life. MTs efficiently bind with high affinity several essential and toxic divalent and monovalent transition metals by forming characteristic polynuclear metal‐thiolate clusters within their structure ...
Jenifer S. Calvo +2 more
openaire +3 more sources
Biomolecules, 2022 Although the pathogenesis of chronic obstructive pulmonary disease (COPD) is not yet fully understood, recent studies suggest that the disruption of the intracellular balance of oxidative (such as reactive oxygen species (ROS)) and antioxidant molecules ...
Ken Ichiro Tanaka +9 more
doaj +1 more source