Results 11 to 20 of about 75,382 (270)

Metal-Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations. [PDF]

Proteins
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
de Oliveira NR, Siqueira AS, Bueno PSA, Gonçalves EC, Zanette J.   +4 more
europepmc   +2 more sources

A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure. [PDF]

J Appl Toxicol
ABSTRACT Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems.
da Luz JZ, de Souza TL, de Almeida Roque A, de Marchi M, Pozzan R, Confortin C, Opuskevitch I, da Silva Ferreira FCA, de Oliveira Ribeiro CA, Neto FF.   +9 more
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Metallothionein Expression and its Influence on the In Vitro Biological Behavior of Mucoepidermoid Carcinoma

Cells, 2020
Mucoepidermoid carcinoma (MEC) is the most common tumor in the salivary glands, often presenting with recurrence and metastasis due to its high invasive capacity.
João Rafael Habib Souza Aquime, Lara Carolina D’Araújo Pinto Zampieri, Maria Sueli da Silva Kataoka, Nelson Antonio Bailão Ribeiro, Ruy Gastaldoni Jaeger, Artur Luiz da Silva, Rommel Thiago Jucá Ramos, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +8 more
doaj   +1 more source

Density and intensity of metallothionein of Crassostrea sp. as biomarkers of heavy metal contamination in the Northern coast of East Java, Indonesia

Egyptian Journal of Aquatic Research, 2021
The present study aimed to observe the expression level of metallothionein by analyzing its density and intensity in the gill and stomach of Crassostrea glomerata and Crassostrea iredalei.
Asus Maizar Suryanto Hertika, Kusriani Kusriani, Erlinda Indrayani, Renanda Baghaz Dzulhamdhani Surya Putra   +3 more
doaj   +1 more source

Metallothionein expression in feline injection site fibrosarcomas

BMC Veterinary Research, 2023
Background Feline injection site fibrosarcoma is an aggressive and infiltrative tumour arising in the background of chronic inflammation. The aim of this study was to evaluate the expression of metallothionein (I-II) in feline injection site ...
Mateusz Mikiewicz, Katarzyna Paździor-Czapula, Joanna Fiedorowicz, Michał Gesek, Iwona Otrocka-Domagała   +4 more
doaj   +1 more source

Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation. [PDF]

, 2012
Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in ...
Donangelo, Carmen, King, Janet
core   +2 more sources

Metallothionein

Experimental Biology and Medicine, 1987
Early research on metallothionein centered on aspects related to a detoxification role. As our understanding of the complex endocrine control that regulates metallothionein gene expression increases, a wider appreciation of a functional role(s) is emerging.
M A, Dunn, T L, Blalock, R J, Cousins
openaire   +2 more sources

A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns [PDF]

, 2010
Petal development and senescence entails a normally irreversible process. It starts with petal expansion and pigment production, and ends with nutrient remobilization and ultimately cell death.
Aharoni, Andersen, Andersson, Basset, Breeze, Brian Thomas, Buchanan-Wollaston, Buchanan-Wollaston, Carol Wagstaff, Chanasut, Channelière, Courtney, Doi, Dudareva, Elizabeth Harrison, Emily Breeze, Eulgem, Fang, Faragher, Ferrante, Fujita, Gibbings, Gombert, Guo, Hall, Hilary Rogers, Hoeberichts, Holton, Hong, Hsiao, Huang, Irene Bramke, Jung, Khodakovskaya, Langston, Le Page-Degivry, Lee, Leverentz, Lim, Lin, Meyer, Mizoguchi, Moyle, Munne-Bosch, Nakashima, Oono, Oono, Panavas, Price, Primack, Rabbani, Ranwala, Ranwala, Reddy, Reid, Roberts, Roca, Rogers, Ross, Rudnicki, Sarah Thornber, Shinozaki, Singh, Takahashi, Tony Stead, van der Krol, van Doorn, van Doorn, Vicky Buchanan-Wollaston, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Weaver, Zhu   +75 more
core   +2 more sources

Isolation and characterisation of metallothionein from the clam Ruditapes decussatus [PDF]

, 2003
Metallothioneins (MT) were obtained after purification from metal-exposed clams (Ruditapes decussatus) using gel-permeation and ion-exchange chromatography.
Bebianno, Bebianno, Bebianno, Berger, Bernhard, Blum, Braun, Brouwer, Chan, Chubatsu, Coleman, Dabrio, Dallinger, Hammer, Kagi, Kagi, Kagi, Kagi, Kagi, Khoo, Kille, Langston, Lin, Lipman, Mackay, Mitra, Narula, Nordberg, Olafson, Pedersen, Raspor, Riek, Robbins, Roesijadi, Roesijadi, Schmidt, Unger, Vasak, Vasak, Wang, Winge, Zeng, Zeng   +42 more
core   +2 more sources