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Methotrexate and bone marrow metaphases
Cancer Genetics and Cytogenetics, 1988The efficacy of a methotrexate (MTX) block/thymidine release synchronization technique has been assessed in bone marrow cultures from patients with acute nonlymphocytic leukemia and myelodysplasia. In contrast to cultures of stimulated lymphocytes from normal individuals, no improvement in mitotic index (MI) or metaphase quality could be detected using
J J, Cunningham +3 more
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Structure of the human centromere at metaphase
Trends in Biochemical Sciences, 1990Until recently the centromere was thought to be a relatively homogeneous region of densely packed heterochromatin with a single differentiated domain--the kinetochore--at its surface, representing the point of attachment of the mitotic spindle. We now know that the centromere of higher eukaryotes is composed of several domains that have been identified
A F, Pluta, C A, Cooke, W C, Earnshaw
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Polyribosome Disaggregation during Metaphase
Science, 1966Polyribosomes as examined by both sucrose-gradient analysis and electron microscopy disaggregate during metaphase in both normal HeLa cells and those arrested in metaphase by treatment with colchicine.
M D, Scharff, E, Robbins
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Metaphase distribution of the mouse chromosomes
Chromosoma, 1972The reports in the literature agree that non-random distribution patterns do occur for the acrocentric human chromosomes in metaphase cell preparations, and it has been suggested that it is a property of acrocentric chromosomes that promotes these non-random patterns.
Spence, campbell M +2 more
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An algorithm for segmentation of metaphase spreads
Pattern Recognition, 1976Abstract An algorithm is proposed for locating chromosomes in photomicrographs of metaphase spreads. The algorithm resembles closely the method used by human operators to search microscopic fields. The algorithm was specially programmed to be used with small scale computers.
G. L. Carayannopoulos, Edward A. Patrick
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FISHing for Damage on Metaphase Chromosomes
2019Fluorescence in situ hybridization (FISH) is used to examine chromosomal abnormalities and DNA damage. Developed in the early 1980s, this technique remains an important tool for understanding chromosome biology and diagnosing genetic disease and cancer.
P Logan, Schuck, Jason A, Stewart
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Metaphase cell finding by machine
Cytogenetics, 2008The basic elements of a mitotic cell-finding machine are described. The hardware components comprising the machine are a motor-controlled microscope, a vidicon scanner and associated video-signal processor, and a digital computer. By very rudimentary signal processing, it is possible to derive an analog voltage from the camera video which is ...
D K, Green, J, Cameron
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Photographic equidensitometry of metaphase chromosomes
Naturwissenschaften, 1978Photographic equidensitometry, which is a procedure to obtain specific lines or symbols for points of equal optical density, has been utilized in the study of chromosome images. Equidensitometric techniques, using a special contour film, permitted three approaches, namely, production of line equidensities (in the form of families, sequences and contour
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ACM SIGGRAPH 2016 Art Gallery, 2016
Russian artist Dmitry Morozov's Metaphase Sound Machine plays off of our increasing dependence on the information and electronic noise that permeates our everyday lives. The project is based on the ideas of American physicist Nick Herbert, who created the Metaphase Typewriter---invented as a quantum device capable of communicating with ghosts---and ...
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Russian artist Dmitry Morozov's Metaphase Sound Machine plays off of our increasing dependence on the information and electronic noise that permeates our everyday lives. The project is based on the ideas of American physicist Nick Herbert, who created the Metaphase Typewriter---invented as a quantum device capable of communicating with ghosts---and ...
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Kinetochores, microtubules and the metaphase checkpoint
Trends in Cell Biology, 1995A decade ago, kinetochores were generally regarded as rather uninteresting structures that served only to attach mitotic chromosomes to microtubules. In the past few years, however, a number of experiments have belied this view and demonstrated that kinetochores are actively involved in moving chromosomes along the microtubules of the mitotic spindle ...
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