Results 171 to 180 of about 1,013,786 (315)

Long-term outcomes and treatment cessation in patients with response to first-line treatment of metastatic prostate cancer. [PDF]

Oncologist
Meeks M, Iranmanesh Y, Song H, Blackford AL, Rasouli A, Baras A, Denmeade SR, Markowski MC, Paller CJ, Carducci MA, Antonarakis ES, Eisenberger MA, Marshall CH.   +12 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies. [PDF]

MedComm (2020)
Zhao Y, Xu W, Wang Y, Huang H, Su Y, Zhou L, Liu J, Guo J.   +7 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Can Radiofrequency Ablation Be Used as a Treatment Modality for the Management of Pulmonary

, 2014
We report the case of a 59-year-old woman who presented with metastatic ameloblastoma involving the lungs, 20 years after resection of the primary tumor in the mandible. The lesions were debulked on multiple occasions with radiofrequency ablation over an
Bill Lees, Jolie Scannell, Metastatic Ameloblastoma   +2 more
core  

Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]

Pigment Cell Melanoma Res
Jarajapu V, Neelature Sriramareddy S, Mecozzi N, Wang K, Karreth FA, Xu X.   +5 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Spatial transcriptomics reveals immune remodeling in lymph nodes of gastric adenocarcinoma. [PDF]

Clin Exp Metastasis
Suwatthanarak T, Nampoolsuksan C, Tanjak P, Thanormjit K, Acharayothin O, Chaiboonchoe A, Suwatthanarak T, Pithukpakorn M, Chalermwai WV, Swangsri J, Methasate A, Chinswangwatanakul V, Parakonthun T.   +12 more
europepmc   +1 more source

Metastatic Endophthalmitis [PDF]

Proceedings of the Royal Society of Medicine, 1933
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source