Results 241 to 250 of about 1,591,450 (336)

An Integrated Dataset of Metastatic Breast Cancer to the Brain with Imaging, Radiomics, and Tumor Genetics. [PDF]

Sci Data
Taha BR, Wu DJ, Sabal LT, Kollitz M, Sloan L, Shoo BA, Yuan J, Hunt M, Park MC, Darrow D, Venteicher AS, Watanabe Y.   +11 more
europepmc   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Hepcidin as an emerging predictor biomarker of leptomeningeal metastases in patients with metastatic breast cancer. [PDF]

BMC Cancer
Delaby C, Al Herk A, Hirtz C, Jacot W, Laigre M, Pouderoux S, Pradeilles N, Lehmann S, Darlix A.   +8 more
europepmc   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

ctDNA detectability and representativeness in seven body liquids from patients with metastatic breast cancer. [PDF]

Nat Commun
Richard F, Maetens M, Van Baelen K, Borremans K, Van Cauwenberge J, Zels G, Rousseau E, Geukens T, De Schepper M, Mahdami A, Vanderheyden E, Van Brussel T, Nguyen HL, Pabba A, Leduc S, Izci H, Bachir I, Carette C, Hatse S, Nysen M, Vermeulen P, Boeckx B, Lambrechts D, Biganzoli E, Neven P, Wildiers H, Van Den Bogaert W, Demeulemeester J, Floris G, Desmedt C.   +29 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Activated glucocorticoid receptor is an estrogen receptor silencer in ER+ metastatic breast cancer. [PDF]

EMBO Mol Med
Manivannan M, Jehanno C, Kloc M, Gomez Miragaya J, Diepenbruck M, Volkmann K, Coissieux MM, Palafox M, Rouchon A, Kramer N, Schmidt A, Blum Y, Hamelin B, Schuster H, Heidinger M, Muenst S, Vetter M, Kurzeder C, Weber WP, Bentires-Alj M.   +19 more
europepmc   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Real-World Clinical Experience of First-Line Ribociclib Combined with an Aromatase Inhibitor in Metastatic Breast Cancer. [PDF]

Cancers (Basel)
Cvetanović AS, Jankovic KB, Stojković AS, Živković ND, Kostić MS, Popović LS.   +5 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source