Results 71 to 80 of about 376,342 (317)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Prospective Multicenter Randomized Phase III Study of Weekly versus Standard Docetaxel (D2) for First-Line Treatment of Metastatic Breast Cancer [PDF]

, 2010
Purpose: Previous phase II studies have indicated a greatly reduced hematotoxicity of docetaxel-based regimens administered on weekly schedules. The present trial was initiated to randomly compare the toxicity and efficacy of weekly docetaxel versus its ...
Abenhardt, Wolfgang, Rauthe, Gerhard, Marion Kiechle, Stemmler, Hans-Joachim, Heinemann, Volker, Harald Sommer, Artmann, Almut, Sommer, Harald, Isolde Gröll de Rivera, Hans-Gerd Meerpohl, de Rivera, Isolde Groell, Meerpohl, Hans-Gerd, Nadia Harbeck, Gerhard Rauthe, Harbeck, Nadia, Volker Heinemann, Kiechle, Marion, Kaiser, Ursula Vehling, Ursula Vehling Kaiser, Wolfgang Abenhardt, Almut Artmann, Hans-Joachim Stemmler   +21 more
core   +1 more source

Metastatic Breast Cancer and Hormonal Receptor Status among a Group of Women in Sub Saharan Africa

The Annals of African Surgery, 2013
Background: Breast cancer is the third commonest cancer in women in Uganda. The majority of breast cancer patients in Uganda present with advanced disease. Many studies show that metastatic lesions frequently lodge in bones, lung and liver.
Nabawanuka A, Galukande M, Nalwoga H, Gakwaya A   +3 more
doaj  

Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer

Cell Communication and Signaling, 2022
Breast cancer is the most common cancer in females, and to date, the mortality rate of breast cancer metastasis cannot be ignored. The metastasis of breast cancer is a complex, staged process, and the pattern of metastatic spread is not random.
Xiaoxiao Chen, Jiamei Feng, Weili Chen, Shijun Shao, Li Chen, Hua Wan   +5 more
doaj   +1 more source

The role of von Willebrand factor in breast cancer metastasis

Translational Oncology, 2021
Breast cancer is the most common female cancer globally, with approximately 12% of patients eventually developing metastatic disease. Critically, limited effective treatment options exist for metastatic breast cancer. Recently, von Willebrand factor (VWF)
Chia Yin Goh, Sean Patmore, Albert Smolenski, Jane Howard, Shane Evans, Jamie O'Sullivan, Amanda McCann   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]

, 2011
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan, Caldwell Helen, Dubois-Marshall, Sylvie, Sylvie Dubois-Marshall, Helen Caldwell, Sims, Andrew H., Sims Andrew H., Elad Katz, Katz Elad, Elad Katz, Meehan Richard R., Meehan, Richard R, Richard R Meehan, Gautier Philippe, David J. Harrison, Richard R, Harrison David J., Gautier, Philippe, Dubois-Marshall Sylvie, Sims, Andrew H, Philippe Gautier, Harrison, David J, David J Harrison, Katz, Elad, Andrew H. Sims, Meehan, Richard R., Andrew H Sims, Caldwell, Helen, Harrison, David J.   +28 more
core   +1 more source

Metastatic Breast Cancer to the Common Bile Duct Presenting as Obstructive Jaundice

Case Reports in Gastroenterology, 2015
Metastatic breast cancer is typically identified in the bones, lymph nodes, lungs and liver. Rarely does metastatic breast cancer involve the common bile duct (CBD) without direct extension from liver metastasis into the CBD. We present a woman diagnosed
Justin Cochrane, Greg Schlepp
doaj   +1 more source

Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer

Journal of Experimental & Clinical Cancer Research, 2021
Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and bone.
Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang, Xiaoxiang Guan   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source