Results 51 to 60 of about 376,342 (317)

Metastatic rectal cancer to the breast

Rare Tumors, 2009
Rectal cancer metastatic to the breast is an exceedingly rare event with around 15 cases reported in the literature. A metastatic breast deposit from the rectum signifies diffuse disseminated disease or a highly aggressive tumor such that surgical intervention other than palliation has a limited role.
Sergio Huerta, Payal Kapur, Prapti Patel, Hsiao C. Li   +3 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Melatonin Does Not Alter Cell Proliferation in Metastatic Breast Cancer Cells

Proceedings, 2018
Breast cancer treatments continue to be investigated with supported by new treatment methods. Melatonin is a hormone that can be effective in the treatment of breast cancer due to its anti-oxidant effect.
Gamze Tanriover, Sayra Dilmac, Nuray Erin   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

An integrated model of the transcriptome of HER2-positive breast cancer [PDF]

, 2013
Our goal in these analyses was to use genomic features from a test set of primary breast tumors to build an integrated transcriptome landscape model that makes relevant hypothetical predictions about the biological and/or clinical behavior of HER2 ...
Melissa Lau, High-seng Chai, David Rossell, Brian M. Necela (224867), Jeanette E. Eckel-Passow (228909), S. Keith Anderson (271824), Tang, Xiaojia, Rossell, David, Kevin J. Thompson (479037), E. Aubrey Thompson (224877), Sarah A McLaughlin, Baker, Tiffany R., Kalari, Krishna R., Necela, Brian M., Xiaojia Tang, Melissa Lau (479038), David Rossell (479046), Lau, Melissa, Derek C Radisky, Krishna R. Kalari (228899), Richard W. Joseph (479042), Sarah A. McLaughlin (479043), Camille, Stephan, Thompson, E. Aubrey, McLaughlin, Sarah A., S Keith Anderson, Saurabh Baheti, Tiffany R Baker, Jennifer M Kachergus, Jennifer M Carr, Joseph, Richard W., Asmann, Yan W., Kachergus, Jennifer M., Yan W. Asmann (210163), Zhifu Sun (60356), Derek C. Radisky (119628), Carr, Jennifer M., Richard W Joseph, Krishna R Kalari, Jennifer M. Carr (224872), Thompson, Kevin J., High-seng Chai (479044), Stephan Camille (479045), Kevin J Thompson, Poulami Barman (479041), Poulami Barman, Edith A Perez, Xiaojia Tang (53518), Saurabh Baheti (479040), Anderson, S. Keith, Barman, Poulami, Brian M Necela, Stephan Camille, Radisky, Derek C., Jennifer M. Kachergus (479039), Eckel-Passow, Jeanette E., Chai, High-seng, Perez, Edith A., Sun, Zhifu, E Aubrey Thompson, Yan W Asmann, Tiffany R. Baker (228915), Zhifu Sun, Baheti, Saurabh, Edith A. Perez (228921), Jeanette E Eckel-Passow   +65 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evolution of breast cancer therapeutics: Breast tumour kinase’s role in breast cancer and hope for breast tumour kinase targeted therapy [PDF]

, 2014
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). © 2014 Baishideng Publishing Group Inc.There have been significant improvements in the detection
Hussain, HA, Harvey, A
core   +1 more source

CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis. [PDF]

PLoS ONE, 2011
Tumor tolerance and immune suppression remain formidable obstacles to the efficacy of immunotherapies that harness the immune system to eradicate breast cancer.
Laura M Hix, Yihui H Shi, Randy R Brutkiewicz, Paul L Stein, Chyung-Ru Wang, Ming Zhang   +5 more
doaj   +1 more source

Breast surgery for metastatic breast cancer

Cochrane Database of Systematic Reviews
Metastatic breast cancer is not curable, but women with this condition are living longer. While breast surgery is not typically part of the treatment for metastatic disease, retrospective studies suggest it might improve survival. These studies have limitations, including selection bias.
Giuliano Tosello, Rachel Riera, Maria Regina Torloni, Teresa Neeman, Marcelo RS Cruz, Ismael Forte Freitas, Diego Christofaro, Thais Reis Silva de Paulo, Crystian B Oliveira, Bruna S Mota   +9 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source