Results 61 to 70 of about 541,152 (293)

Metastatic Breast Cancer and Hormonal Receptor Status among a Group of Women in Sub Saharan Africa

The Annals of African Surgery, 2018
Background: Breast cancer is the third commonest cancer in women in Uganda. The majority of breast cancer patients in Uganda present with advanced disease. Many studies show that metastatic lesions frequently lodge in bones, lung and liver.
Nabawanuka A, Galukande M, Nalwoga H, Gakwaya A   +3 more
doaj  

Associations Between Serum Soluble Toll-like Receptors 4 and 9 and Breast Cancer in Egyptian Patients

Cancer Control, 2023
Background Toll-like receptors (TLRs) play an important role in regulation of immune cells and are vital in tumorigenesis due to its crucial role in inflammatory microenvironment regulation, as they promote the synthesis and release of inflammatory ...
Inas Moaz, Fayrouz A. Fouad, Hossam Elmasry, Gehad Tarek, Aya Elzoheiry, Manar Elgamal, Randa Ibrahim, Yasmin Hisham, Gehan Safwat, Mahmoud M. Kamel, Heba M. El-Batal, Merhan Fouda   +11 more
doaj   +1 more source

IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment

Frontiers in Oncology, 2021
Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging as ...
Amanda M. Clark, Amanda M. Clark, Amanda M. Clark, Haley L. Heusey, Haley L. Heusey, Linda G. Griffith, Douglas. A. Lauffenburger, Alan Wells, Alan Wells, Alan Wells, Alan Wells   +10 more
doaj   +1 more source

MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells [PDF]

, 2018
Mir-205 plays an important role in epithelial biogenesis and in mammary gland development but its role in cancer still remains controversial depending on the specific cellular context and target genes.
De Cola A., De Laurenzi V., Iezzi M., Lamolinara A., Lanuti P., Marchisio M., Rossi C., Todaro M.   +7 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.

PLoS Genetics, 2022
The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was higher in breast cancers
Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, Justin Lack, Jennifer E Dwyer, R Mark Simpson, Christophe Cataisson, Max P Lee, Ji Luo, Kent W Hunter, Stuart H Yuspa   +12 more
doaj   +1 more source

First-line therapy in HER2 positive metastatic breast cancer. Is the mosaic fully completed or are we missing additional pieces? [PDF]

, 2016
The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outcomes for women with early-stage and advanced ...
Cognetti F., Fabi A., Malaguti P., Vari S.   +3 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Metastatic Breast Cancer and Hormonal Receptor Status among a Group of Women in Sub Saharan Africa

The Annals of African Surgery, 2013
Background: Breast cancer is the third commonest cancer in women in Uganda. The majority of breast cancer patients in Uganda present with advanced disease. Many studies show that metastatic lesions frequently lodge in bones, lung and liver.
Nabawanuka A, Galukande M, Nalwoga H, Gakwaya A   +3 more
doaj  

Clinical relevance of circulating biomarkers in breast cancer metastasis detection: "insights from liquid biopsy technology"

Research in Pharmaceutical Sciences
Background and purpose: Breast cancer is a major global concern, especially because of high mortality linked to advanced stages. Metastasis may occur early, but current diagnostics struggle to detect small metastatic cells.
Zohreh Salimi, Rasoul Fatehifard, Mahmoud Aghaei, Mojtaba Panjehpour   +3 more
doaj   +1 more source