Results 61 to 70 of about 376,342 (317)

Occult Breast Carcinoma Presenting as Scalp Metastasis

Case Reports in Oncology, 2017
Breast cancer is the most common tumor among women, and approximately 6% of the patients have de novo metastatic breast cancer. Occult breast cancer accounts for only 0.1–0.8% of the cases and most commonly presents with axillary lymphadenopathy.
Ricardo L.B. Costa, Rubens B. Costa-Filho, Marilin Rosa, Brian J. Czerniecki   +3 more
doaj   +1 more source

Associations Between Serum Soluble Toll-like Receptors 4 and 9 and Breast Cancer in Egyptian Patients

Cancer Control, 2023
Background Toll-like receptors (TLRs) play an important role in regulation of immune cells and are vital in tumorigenesis due to its crucial role in inflammatory microenvironment regulation, as they promote the synthesis and release of inflammatory ...
Inas Moaz, Fayrouz A. Fouad, Hossam Elmasry, Gehad Tarek, Aya Elzoheiry, Manar Elgamal, Randa Ibrahim, Yasmin Hisham, Gehan Safwat, Mahmoud M. Kamel, Heba M. El-Batal, Merhan Fouda   +11 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. [PDF]

, 2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy.
Ulrich Pfeffer, Killian, Peter H., Fichtner Iduna, Efferth, Thomas, Iduna Fichtner, Pfeffer Ulrich, Pfeffer, U., Emanuel Kronski, Bachmeier Beatrice, Killian, P.H., Fichtner, I., Beatrice Bachmeier, Bachmeier, B., Thomas Efferth, Kronski, Emanuel, Efferth Thomas, Kronski, E., Pfeffer, Ulrich, Fichtner, Iduna, Bachmeier, Beatrice, Peter H. Killian, Peter H Killian, Efferth, T., Kronski Emanuel, Killian Peter H.   +24 more
core   +1 more source

Metastatic Breast Cancer and Hormonal Receptor Status among a Group of Women in Sub Saharan Africa

The Annals of African Surgery, 2018
Background: Breast cancer is the third commonest cancer in women in Uganda. The majority of breast cancer patients in Uganda present with advanced disease. Many studies show that metastatic lesions frequently lodge in bones, lung and liver.
Nabawanuka A, Galukande M, Nalwoga H, Gakwaya A   +3 more
doaj  

IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment

Frontiers in Oncology, 2021
Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging as ...
Amanda M. Clark, Amanda M. Clark, Amanda M. Clark, Haley L. Heusey, Haley L. Heusey, Linda G. Griffith, Douglas. A. Lauffenburger, Alan Wells, Alan Wells, Alan Wells, Alan Wells   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Quantifying metastatic inefficiency:rare genotypes versus rare dynamics [PDF]

, 2014
We introduce and solve a 'null model' of stochastic metastatic colonization. The model is described by a single parameter ?: the ratio of the rate of cell division to the rate of cell death for a disseminated tumour cell in a given secondary tissue ...
Newman, Timothy J., Cisneros, Luis H.
core   +1 more source

Clinical relevance of circulating biomarkers in breast cancer metastasis detection: "insights from liquid biopsy technology"

Research in Pharmaceutical Sciences
Background and purpose: Breast cancer is a major global concern, especially because of high mortality linked to advanced stages. Metastasis may occur early, but current diagnostics struggle to detect small metastatic cells.
Zohreh Salimi, Rasoul Fatehifard, Mahmoud Aghaei, Mojtaba Panjehpour   +3 more
doaj   +1 more source

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.

PLoS Genetics, 2022
The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was higher in breast cancers
Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, Justin Lack, Jennifer E Dwyer, R Mark Simpson, Christophe Cataisson, Max P Lee, Ji Luo, Kent W Hunter, Stuart H Yuspa   +12 more
doaj   +1 more source