Results 161 to 170 of about 6,340,743 (257)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Cabozantinib-associated therapy-refractory lower-leg ulcers in metastatic renal cell carcinoma. [PDF]

JAAD Case Rep
Meng Z, Franz TM, Hindelang B, Steimle-Grauer SA, Biedermann T.   +4 more
europepmc   +1 more source

Old disease, new twist

Journal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Characteristics of ascitic fluid and diagnosis of bacterial peritonitis in malignant ascites: An observational study

Journal of Hospital Medicine, EarlyView.
Abstract Background Bacterial peritonitis in patients with malignant ascites (BP‐MA) is an understudied, high‐mortality condition. While ascitic polymorphonuclear (PMN) cell count ≥ 250 cells/mm3 defines the diagnosis of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis, an ascitic fluid parameter for the diagnosis of BP‐MA has not ...
Mark M. Kelly, Nicole Johnston, Joanne Kuznicki, Stacy A. Johnson, Hannah Imlay   +4 more
wiley   +1 more source

Acrometastasis as an Initial Sign of Progression in Untreated Metastatic Renal Cell Carcinoma: A Case Report. [PDF]

Cureus
Tan LR, Lee TMY, Chia PL, Tang YL, Choo ZW.   +4 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Pelvic Exenteration for Cervical Cancer: Oncological, Morbidity and Quality of Life Outcomes

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives One third of patients who undergo definitive chemoradiotherapy for locally advanced cervical cancer develop disease recurrence. Salvage surgery in the form of pelvic exenteration (PE) may offer improved survival and possibly cure in carefully selected patients, however robust data is scarce.
Alexandra M. Peacock, Kilian G.M. Brown, Peter J. M. Lee, Kirk K. S. Austin, Christopher M. Byrne, Daniel Steffens, Michael J. Solomon   +6 more
wiley   +1 more source

International metastatic renal cell carcinoma database consortium classification and regression tree analysis to characterize objective response rates to first line in metastatic renal cell carcinoma. [PDF]

Front Oncol
Zarba M, O'Sullivan D, Maj D, Cheung WY, Ludwig L, Wells C, Ferrier E, El Hajj Chehade R, Donskov F, Eid M, Pal SK, Beuselinck B, McKay RR, Wood L, Lee JL, Suárez C, Takemura K, Duran I, Choueiri TK, Heng DY.   +19 more
europepmc   +1 more source

Ultra‐High Frequency Ultrasound Imaging and Quantification of Microvascular Flow in Xenograft Renal Cell Carcinoma in an Avian Chorioallantoic Membrane Model

Journal of Ultrasound in Medicine, EarlyView.
Patient‐derived xenograft (PDX) tumor models initiated in avian chorioallantoic membranes (CAM) are under investigation to evaluate the effectiveness of therapeutic options with the objective of personalizing treatments. CAM PDXs paired with ultra‐high frequency ultrasound (UHFUS) imaging could potentially constitute prospective high throughput assays ...
Sara Mar, Emmanuel Chérin, Justin Xu, David E. Goertz, Hon S. Leong, Christine E.M. Demore   +5 more
wiley   +1 more source

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source