Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer [PDF]
Journal of experimental & clinical cancer research : CR, 2021 Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer.
Jing‐Jing Yang +13 more
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A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar +5 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee +15 more
doaj +1 more source
Metformin: update on mechanisms of action and repurposing potential
Nature Reviews Endocrinology, 2023 Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients.
M. Foretz, B. Guigas, B. Viollet
semanticscholar +1 more source
Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Journal of Translational Medicine, 2023 Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts the distinct advantages of an excellent safety and tolerability profile and high cost-effectiveness at ...
Y. Hua +5 more
semanticscholar +1 more source
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
British Journal of Cancer, 2023 Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical
S. Lord, A. Harris
semanticscholar +1 more source
A study on metformin-induced anemia using red blood cell indices and red cell distribution width
Assam Journal of Internal Medicine, 2023 Background: Diabetic patients on metformin may have increased risk of developing anemia. Hematological parameters can easily reflect anisocytosis and differential analysis of anemia.
Sasank Lingam +2 more
doaj +1 more source
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Nature, 2022 Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ...
Teng Ma +34 more
semanticscholar +1 more source
Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress
Frontiers in Cell and Developmental Biology, 2022 Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins +12 more
doaj +1 more source
Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes. [PDF]
PLoS ONE, 2018 OBJECTIVE:Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry +8 more
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