Results 11 to 20 of about 320,201 (374)

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Frontiers in Cell and Developmental Biology, 2022
Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins, India G. Robinson, Rebecca M. Reynolds, Irving L. M. H. Aye, Irving L. M. H. Aye, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones, Benjamin Jenkins, Albert Koulmann, Susan E. Ozanne, Catherine E. Aiken, Catherine E. Aiken, Catherine E. Aiken   +12 more
doaj   +1 more source

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing

Journal of Translational Medicine, 2023
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts the distinct advantages of an excellent safety and tolerability profile and high cost-effectiveness at ...
Y. Hua, Yue Zheng, Yiran Yao, Renbing Jia, S. Ge, Zhuang Ai   +5 more
semanticscholar   +1 more source

Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes. [PDF]

PLoS ONE, 2018
OBJECTIVE:Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry, Juan P Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A Bicsak, Alain Baron, Mark Fineman   +8 more
doaj   +1 more source

A study on metformin-induced anemia using red blood cell indices and red cell distribution width

Assam Journal of Internal Medicine, 2023
Background: Diabetic patients on metformin may have increased risk of developing anemia. Hematological parameters can easily reflect anisocytosis and differential analysis of anemia.
Sasank Lingam, Himavathy Kodandarao Gara, Dharma Rao Vanamali   +2 more
doaj   +1 more source

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]

, 2020
High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ, Finegan, KG, Kitson, S, Latif, A, Lisanti, MP, Marshall, K, McVey, R, Sivalingam, VN, Sotgia, F, Stratford, IJ   +9 more
core   +2 more sources

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
AN Macintyre, AS Green, Benoit Viollet, C Grimaldi, David K. Finlay, DG Hardie, Doreen A. Cantrell, EL Pearce, EL Pearce, GD Holman, I Ben Sahra, JD Powell, K Araki, LV Sinclair, M Foretz, M Zarrouk, Marc Foretz, Marouan Zarrouk, MR Owen, N Nath, N Zhang, NJ MacIver, NJ MacIver, P Tamas, Ping Song, R Wang, R Wang, RA Miller, RD Michalek, S He   +29 more
core   +7 more sources

Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin

Molecules, 2021
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects.
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz   +5 more
doaj   +1 more source

Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

Drug Design, Development and Therapy, 2023
Metformin has been designated as one of the most crucial first-line therapeutic agents in the management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent, metformin also has a plethora of pleiotropic effects on various systems and ...
S. Dutta, R. Shah, S. Singhal, S. Dutta, S. Bansal, Susmita Sinha, Mainul Haque   +6 more
semanticscholar   +1 more source

Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

BMJ Open Diabetes Research & Care, 2020
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy.
Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten   +11 more
doaj   +1 more source

Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan

BMJ Open Diabetes Research & Care, 2020
Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.Methodology Between May 2018 and January 2019, this prospective multicenter observational study recruited ...
Asher Fawwad, Nazish Waris, Bilal Tahir, Sobia Sabir Ali, Qazi Masroor, Salma Tanveer, Jamal Zafar, Zahid Miyan, Khalid Usman, Khursheed Ahmed, Riaz A Malik   +10 more
doaj   +1 more source