Results 11 to 20 of about 113,390 (232)
Clinical and Translational Medicine, 2023 Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska +9 more
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‘Massive’ metformin overdose [PDF]
British Journal of Clinical Pharmacology, 2018 Massive metformin overdose can cause metabolic acidosis with hyperlactatemia. A 55‐year‐old woman presented 5 h after multidrug overdose, including 132 g extended‐release metformin. Continuous venovenous haemodiafiltration (CVVHDF) and noradrenaline were commenced due to metabolic acidosis (pH 7.0, lactate 17 mmol l–1) and shock. Despite 3 h of CVVHDF,
Angela L. Chiew +7 more
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Journal of Clinical & Translational Endocrinology, 2018 Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum +3 more
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Jurnal Urologi Indonesia, 2020 Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol +3 more
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Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner
OncoImmunology, 2021 Metformin, a drug prescribed to treat type 2 diabetes, has been reported to possess antitumor activity via immunity activation. However, the influence of metformin on natural killer (NK) cells is not fully understood.
Wenjiao Xia +7 more
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Frontiers in Pharmacology, 2021 The purpose of this study was to analyze the time course and dose effect from metformin on body mass index (BMI) in children and adolescents by model-based meta-analysis (MBMA).
Dong-Dong Wang +5 more
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PLoS ONE, 2018 ObjectiveMetformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry +8 more
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Drugs in R & D, 2005 Metformin extended release [Glumetza, metformin hydrochloride, metformin gastric retention, metformin GR] is a proprietary once-a-day formulation of metformin hydrochloride under development with Depomed for the treatment of diabetes mellitus. In May 2002, Depomed licensed manufacturing and marketing rights for its proprietary formulation of metformin ...
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Metformin from mother to unborn child – Are there unwarranted effects?
EBioMedicine, 2018 For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus.
Linh Nguyen +2 more
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Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. [PDF]
PLoS ONE, 2015 Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth.
Yoko Tsutsumi +9 more
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