Results 271 to 280 of about 205,038 (298)

Virtual Bioequivalence Assessment and Dissolution Safe Space Exploration for Fixed-Dose Metformin-Glyburide Tablet Using Physiologically Based Biopharmaceutics Modeling. [PDF]

Pharmaceutics
Zhao C, Shen C, Xiao Y, Wang L.
europepmc   +1 more source

Defining Microbiota‐Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age‐Related T Cell Senescence

Aging Cell, EarlyView.
An age‐associated accumulation of senescent T cells is characterized by increased cellular damage and the secretion of pro‐inflammatory molecules collectively known as the senescence‐associated secretory phenotype (SASP). In the present study, we demonstrate that this accumulation of senescent T cells in aged hosts is accompanied by a reduction in ...
Nia Paddison Rees, Jessica Conway, Ben Dugan, Sayeda S. Amir, Aimee Parker, Simon R. Carding, Niharika A. Duggal   +6 more
wiley   +1 more source

Gastric Emptying Delay with Pre-Meal Administration of Metformin and Anagliptin in Type 2 Diabetes: Effects on Postprandial Glucose and Triglyceride Levels in a Two-Case Report. [PDF]

Am J Case Rep
Murata K, Sato D, Morino K, Ida S, Ohashi N, Takenaka D, Kitagawa N, Shigemi M, Miyazawa I, Yanagimachi T, Fujita Y, Maegawa H, Kume S.   +12 more
europepmc   +1 more source

An Ad Libitum‐Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts via Opposite Effects on the Energy‐Splicing Axis

Aging Cell, EarlyView.
Caloric restriction (CR) and an ad libitum‐fed low‐protein, high‐carbohydrate, high‐fibre (LPHC) diet both improve longevity and metabolic health relative to a control diet. Liver proteomics revealed CR alone increased proteins associated with mitochondrial pathways and energy metabolism.
Amanda E. Brandon, Tamara Pulpitel, Carsten Schmitz‐Peiffer, Lewin Small, Alistair M. Senior, Sophie Stonehouse, Letisha Prescott, Alyssa Face, K. Saiful Islam, Jenny E. Gunton, Jacob George, David Raubenheimer, Gregory J. Cooney, David G. Le Couteur, Stephen J. Simpson   +14 more
wiley   +1 more source

Synergistic Effects of Naringenin and Metformin on Dyslipidemia and Glucose Regulation in High Fructose-Fed Rats. [PDF]

Adv Biomed Res
Salimi M, Sadeghimahalli F, Ehsani Vostacolaee S, Molayi MS, Amiri A.   +4 more
europepmc   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Plain Language Summary of the ACCEPT Guideline for the Management of Recurrent Pregnancy Loss

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Recurrent pregnancy loss (RPL) is when a woman experiences two or more pregnancy losses. Investigating for causes of RPL can provide an explanation and possible treatment options. This is a summary of Parts 1 and 2 of Australasian Recurrent Pregnancy Loss Clinical Management Guidelines in an easy‐to‐read patient friendly format. These original
Adriana Suker, Ying Li, Anthony Marren, Danielle Robson, the Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial evidence (ACCEPT) group   +4 more
wiley   +1 more source

Risk of hyperlactatemia in patients with obstructive sleep apnea receiving metformin: a cross-sectional study. [PDF]

Sleep Breath
Kania A, Polok K, Celejewska-Wójcik N, Nastałek P, Sładek K, Bochenek G.   +5 more
europepmc   +1 more source

ACCEPT Group Condensed Position Paper on the Management of Recurrent Pregnancy Loss

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT The Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) group recently published an evidence‐based guideline on the investigation and management of recurrent pregnancy loss (RPL).
Adriana Suker, Ying Li, Anthony Marren, Danielle Robson, the Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial evidence (ACCEPT) Group   +4 more
wiley   +1 more source

Obesity-induced NLRP3 inflammasome activation in nucleus pulposus cells accelerates intervertebral disk degeneration. [PDF]

J Orthop Surg Res
Gao S, Su NN, Zhao Q, Wang FF, Wang SC, Guo W.   +5 more
europepmc   +1 more source