Results 41 to 50 of about 297,887 (387)

Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study

open access: yesFrontiers in Medicine, 2021
Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis remains limited. There still was a controversial about association between preadmission metformin use and mortality in sepsis patients with diabetes.
Qilin Yang   +7 more
semanticscholar   +1 more source

COMPARISON OF BLADDER CANCER CELLS APOPTOSIS INDUCED BY METFORMIN, CISPLATIN, AND COMBINATION OF METFORMIN-CISPLATIN: IN VITRO STUDY

open access: yesJurnal Urologi Indonesia, 2020
Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol   +3 more
doaj   +1 more source

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

open access: yesClinical and Translational Medicine, 2023
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska   +9 more
doaj   +1 more source

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

open access: yes, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua   +10 more
core   +2 more sources

The mechanisms of action of metformin

open access: yesDiabetologia, 2017
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
G. Rena, D. Hardie, E. Pearson
semanticscholar   +1 more source

Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. [PDF]

open access: yesPLoS ONE, 2015
Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth.
Yoko Tsutsumi   +9 more
doaj   +1 more source

Metformin reverses development of pulmonary hypertension via aromatase inhibition [PDF]

open access: yes, 2016
Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP ...
Dean, Afshan   +4 more
core   +2 more sources

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage

open access: yesJournal of Clinical & Translational Endocrinology, 2018
Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum   +3 more
doaj   +1 more source

A new perspective on metformin therapy in type 1 diabetes [PDF]

open access: yes, 2017
Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G.   +2 more
core   +1 more source

Pioglitazone and metformin

open access: yesDrugs of Today, 2007
Pioglitazone and metformin have both proven safe and efficacious in the treatment of type 2 diabetes. Their combination into a single tablet seems logical. This article reviews the data that are available for this combination. Because the tablets are not currently widely available, the review examines some aspects of the effects of both agents ...
Hill, N, Matthews, DR
openaire   +4 more sources

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