Results 41 to 50 of about 205,038 (298)
Intracerebroventricular Injection of Metformin Induces Anorexia in Rats [PDF]
Diabetes & Metabolism Journal, 2012 BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin ...
Chang Koo Lee +5 more
doaj +1 more source
Frontiers in Medicine, 2021 Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis remains limited. There still was a controversial about association between preadmission metformin use and mortality in sepsis patients with diabetes.
Qilin Yang +7 more
semanticscholar +1 more source
Metformin from mother to unborn child – Are there unwarranted effects?
EBioMedicine, 2018 For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus.
Linh Nguyen +2 more
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Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
Cell Reports, 2016 Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans.
Adam R. Konopka +9 more
doaj +1 more source
Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. [PDF]
PLoS ONE, 2015 Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth.
Yoko Tsutsumi +9 more
doaj +1 more source
Protein & Cell, 2021 Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases. However, the mechanisms that regulate CMA are not fully understood.
Xiaoyan Xu +14 more
semanticscholar +1 more source
Should metformin remain the first-line therapy for treatment of type 2 diabetes?
Therapeutic Advances in Endocrinology and Metabolism, 2021 Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.
Chelsea Baker +5 more
semanticscholar +1 more source
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. [PDF]
PLoS ONE, 2012 Metformin inhibits ATP production in mitochondria and this may be involved in the anti-hyperglycemic effects of the drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates the function of the electron transport chain and maintains ...
Marcin Buler +3 more
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Journal of Pharmacological Sciences, 2021 Introduction: Heart failure is the final pathway for a wide spectrum of myocardial stress, including hypertension and myocardial infarction. However, the potential effects of metformin on cardiac hypertrophy are still unclear.
Yoichi Sunagawa +10 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source