Results 21 to 30 of about 4,988 (166)

HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization

Respiratory Research, 2020
Background This study was to investigate of the mechanism by which histone deacetylase (HDAC) 8 inhibitor ameliorated airway hyperresponsiveness (AHR) and allergic airway inflammation.
Meng-lu Li, Xin-ming Su, Yuan Ren, Xuan Zhao, Ling-fei Kong, Jian Kang   +5 more
doaj   +1 more source

Osmoregulation by the Broad-Snouted Caiman, "Caiman latirostris", in Estuarine Habitat in Southern Brazil [PDF]

, 1998
The broad-snouted caiman Caiman latirostris, of South America mostly frequents freshwater but occurs also in estuaries. Nothing of substance is known of its osmoregulatory physiology but, in the light of accumulating evidence that alligatorids lack ...
Beard, L. A., Grigg, G. C., Moulton, T., Queirol Melo, M. T., Taplin, L. E.   +4 more
core   +1 more source

Issues Determining Direct Airways Hyperresponsiveness in Mice

Frontiers in Physiology, 2012
Airways hyperresponsiveness (AHR) is frequently a primary outcome in mouse models of asthma. There are, however, a number of variables that may affect the outcome of such measurements and the interpretation of the results.
Lennart Karl, Alf Lundblad
doaj   +1 more source

The effect of L-arginine on guinea-pig and rabbit airway smooth muscle function in vitro

Brazilian Journal of Medical and Biological Research, 1998
We have investigated the effects of L-arginine, D-arginine and L-lysine on airway smooth muscle responsiveness to spasmogens in vitro. Both L-arginine and D-arginine (100 mM) significantly reduced the contractile potency and maximal contractile response ...
A.C. Perez, W. Paul, S. Harrison, C.P. Page, D. Spina   +4 more
doaj   +1 more source

Influence of lung parenchymal destruction on the different indexes of the methacholine dose-response curve in COPD patients [PDF]

, 2000
STUDY OBJECTIVES: The interpretation of nonspecific bronchial provocation dose-response curves in COPD is still a matter of debate.
Boere-van der Straat, S., Bogaard, J.M. (Jan), Hoogsteden, H.C. (Henk), Verbraak, A.F.M. (Anton), Verhoeven, G.T.   +4 more
core   +2 more sources

Molecular and pharmacological characterization of an acetylcholine-gated chloride channel (ACC-2) from the parasitic nematode Haemonchus contortus

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Nematode cys-loop ligand-gated ion channels (LGICs) have been shown to be attractive targets for the development of novel anti-parasitic drugs. The ACC-1 family of receptors are a unique group of acetylcholine-gated chloride channels present only in ...
Sarah A. Habibi, Micah Callanan, Sean G. Forrester   +2 more
doaj   +1 more source

Lingual Salt Glands in Crocodylus acutus and C. johnstoni and Their Absence from Alligator mississipiensis and Caiman crocodilus [PDF]

, 1982
1. Lingual salt glands, secreting hyperosmotic Na/K solutions in response to methacholine, are present in Crocodylus acutus and C. johnstoni but apparently absent from the alligatorids, Alligator mississipiensis and Caiman crocodilus. 2.
AM Reese, AM Reese, DH Evans, GC Grigg, GC Grigg, Gordon C. Grigg, H Messel, H Taguchi, L Ferdinand, Laurence E. Taplin, LE Taplin, M Peaker, Peter Harlow, R Owen, Tamir M. Ellis, WA Dunson, WA Dunson, WA Dunson, WA Dunson, William A. Dunson, WT Neill   +20 more
core   +1 more source

Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: relationship with the atopic status [PDF]

, 2003
An increased prevalence of bronchial hyper-responsiveness (BHR) has been demonstrated in children from a general population, and in non-asthmatic adults with allergic rhinitis.
Bonsignore, G., Bucchieri, S, Cibella, F, Cuttitta, G, Hopps, M, LA GRUTTA, Stefania, Passalacqua, G   +6 more
core   +1 more source

Protector mechanisms of the association between gastroesophageal reflux disease and asthma: experimental study in rats Mecanismos protetores: doença do refluxo gastroesofágico e asma. Estudo experimental em ratos

Arquivos de Gastroenterologia, 2008
BACKGROUND: It is well known the association between gastroesophageal reflux disease and asthma. The hyperreactivity of the airways is a characteristic of an asthmatic.
Paula Yuri Sugishita Kanikadan, Jayme Antonio Aboin Sertié, Ricardo Martins Oliveira-Filho, Wothan Tavares de Lima   +3 more
doaj   +1 more source

Effect of pH on the stability of methacholine chloride in solution

Respiratory Medicine, 1998
Methacholine chloride bronchoprovocation challenges are performed for the diagnosis and investigation of hyperreactive airways. Over the last 20 yrs various formulations and pH values for the preparation of solutions of methacholine have been described.
Watson, B.L., Cormier, R.A., Harbeck, R.J.   +2 more
openaire   +2 more sources