Results 41 to 50 of about 4,988 (166)

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L., Alikhani V., Anderson G. P., Austin R. P., Bao Y., Baur F., Bouyssou T., Cazzola M., Connolly S., Cooper A. E., Davies S. L., Deyrup M. D., Fuso L., Giles M. E., Green S. A, Kuna P., Matera M. G., Mortimer K. J., Patton J. S., Procopiou P. A., Procopiou P. A., Roig J., Stocks M. J., Tayab Z. R., Walker J. K. L., Walland A., White M. V.   +26 more
core   +2 more sources

Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus

European Journal of Neuroscience, Volume 62, Issue 1, July 2025.
In this current study, we investigated the cellular mechanisms underlying dopaminergic modulation in the hippocampus by combining pharmacology and electrophysiology in organotypic hippocampal slices. We identified that dopamine D2 receptors are expressed in somatostatin and, to a lesser extent, parvalbumin interneurons.
Pola Tuduri, Audrey Mignon, Emmanuel Valjent, Jeanne Ster   +3 more
wiley   +1 more source

Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects. [PDF]

, 2012
This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine
Gilani, Anwar, Shah, Abdul Jabbar
core   +1 more source

Systemic EP4 receptor agonist and Arginase‐1 therapy in a murine model of chronic asthma and influenza virus‐induced asthma exacerbation

British Journal of Pharmacology, Volume 182, Issue 12, Page 2803-2820, June 2025.
Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange, Tobias Brunn, Charlotte Vetter, Konstantin Bloch, Nora Vedder, Chiel van Geffen, Philipp Gercke, Saeed Kolahian   +7 more
wiley   +1 more source

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. [PDF]

, 2012
Emerging evidence suggests that the T helper 17 (T(H)17) subset of αβ T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the αvβ8 integrin on dendritic cells did not generate T(H)17 cells in the lung and ...
Atabai, Kamran, Bernstein, Xin, Chen, Chun, Engler, Mary B, Huang, Katherine E, Huang, Xiaozhu, Kudo, Makoto, Li, John T, Melton, Andrew C, Ren, Xin, Sheppard, Dean, Wang, Yanli   +11 more
core   +1 more source

Change of bronchial hyperresponsiveness in asthmatic children [PDF]

, 2011
Introduction. Bronchial hyperresponsiveness (BHR) is a factor in predicting bronchial asthma independently of inflammation markers. Objective. The aims were to determine the frequency and important predictive facts of BHR and the effect of prophylaxis
Obradović Slobodan, Radlović Nedeljko, Stojković-Anđelković Anđelka, Vuletić Biljana   +3 more
core   +1 more source

Involvement of mitogen-activated protein kinases in mast cell mediator induced airway hyper-responsiveness in guinea pig trachea [PDF]

, 2016
Introduction: Exposure to allergens causes activation of mast cells and release of its mediators leading to airway constriction. Airway hyper-responsiveness (AHR) is a major characteristic of asthma but understanding of its causes is incomplete. Theories
Belikova, Maria
core  

STING‐dependent induction of neutrophilic asthma exacerbation in response to house dust mite

Allergy, Volume 80, Issue 3, Page 715-737, March 2025.
This study investigates whether STING‐induced neutrophilic lung inflammation mimics severe asthma. STING activation during allergic challenge triggers neutrophilic asthma accompanied by a Th1 and pro‐inflammatory cytokine in addition to the Th2 cytokines resulting in an epithelial barrier damage, cell death and self‐dsDNA release with increased mucus ...
Yasmine Messaoud‐Nacer, Elodie Culerier, Stéphanie Rose, Isabelle Maillet, Rania Boussad, Chloé Veront, Florence Savigny, Bernard Malissen, Urszula Radzikowska, Milena Sokolowska, Gabriel V. L. da Silva, Michael R. Edwards, David J. Jackson, Sebastian L. Johnston, Bernhard Ryffel, Valerie F. Quesniaux, Dieudonnée Togbe   +16 more
wiley   +1 more source

Mechanical correlates of dyspnea in bronchial asthma. [PDF]

, 2013
We hypothesized that dyspnea and its descriptors, that is, chest tightness, inspiratory effort, unrewarded inspiration, and expiratory difficulty in asthma reflect different mechanisms of airflow obstruction and their perception varies with the severity ...
A., Antonelli, C., Gulotta, Dellaca', Raffaele, E., Crimi, G., Scano, Gobbi, Alessandro, R., Pellegrino, R., Torchio, V., Brusasco   +8 more
core   +1 more source

Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring

Advanced Science, Volume 12, Issue 2, January 13, 2025.
Bioreceptor‐based wearable electrochemical sensors have opened new avenues for on‐body and continuous molecular detections, enabling personalized and preventive healthcare. This review summarises recent innovations and applications of those wearable biosensing systems in detecting a variety of biochemical markers, such as small molecules, hormones ...
Haowei Duan, Shuhua Peng, Shuai He, Shi‐Yang Tang, Keisuke Goda, Chun H. Wang, Ming Li   +6 more
wiley   +1 more source