Results 161 to 170 of about 10,913 (208)

[Methimazole versus methimazole and diphosphonates in hyperthyroid and osteoporotic patients].

Minerva endocrinologica, 2005
It is well-know that hyperthyroidism is one of the key causes of secondary osteoporosis. High values of thyroid hormones increase the bone mineral turnover speed by promoting osteoclastic and osteoblastic activities. The aim of our study is to evaluate the increase of bone mineral density (BMD) in osteoporotic and hyperthyroid patients treated with ...
LUPOLI GA, FITTIPALDI MR, FONDERICO F, PANICO A, COLARUSSO S, DI MICCO L, CAVALLO A, COSTA L, PAGLIONE A, LUPOLI, GIOVANNI   +9 more
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Mechanisms of Antithyroidal Activity of Methimazole

Journal of Pharmaceutical Sciences, 1966
Methimazole produces a significant inhibition of iodide ion absorption by the intact thyroid which may account for the major portion of its antithyroidal action. The principal intrathyroidal effect of methimazole is shown to be due to its reactivity with elemental iodine.
R E, Brock, W F, Head
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The Effects of Methimazole on Haematopoiesis in Mice

Immunopharmacology and Immunotoxicology, 1995
The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks.
N K, Mak, W H, Lai, W K, Liu, K N, Leung, M C, Fung   +4 more
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Methimazole and Arthritis

Scandinavian Journal of Rheumatology, 1990
(1990). Methimazole and Arthritis. Scandinavian Journal of Rheumatology: Vol. 19, No. 5, pp. 385-385.
openaire   +1 more source

Anti-Inflammatory Action of Methimazole

Pharmacology, 2008
The anti-inflammatory activity of 1-methylimidazole-2-thiol (methimazole), the most widely used antithyroid drug, was investigated. Methimazole had a marked inhibitory action on prostaglandin H synthase (IC₅₀ = 10 µmol/l), inhibiting the peroxidase (IC₅₀ = 330 µmol/l), although the cyclo-oxygenase was ...
J F, Lagorce, T, Moulard, A, Rousseau, F, Comby, J, Buxeraud, C, Raby   +5 more
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Methimazole: An Alternative Route of Administration*

The Journal of Clinical Endocrinology & Metabolism, 1982
Methimazole was administered orally and rectally in a single dose of 60 mg to six euthyroid volunteers (three females and three males). Blood levels of methimazole were the same whether administered by the oral or rectal route, with peak levels of 1184 +/- 118 and 1163 +/- 150 (+/-SEM) ng/ml respectively.
N, Nabil, D J, Miner, J M, Amatruda
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Potentiometric and voltammetric determination of methimazole

Journal of Pharmaceutical and Biomedical Analysis, 2003
The determination of methimazole was investigated by potentiometric titration in an alkaline medium involving its reaction with iodine and square wave voltammetry (SWV) in 0.1 mol/l Tris-HCl buffer at pH 7.2. In potentiometric titration, the range of determination was 10-500 micromol.
Mehmet, Aslanoglu, Nesrin, Peker
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Excretion of methimazole in human milk

European Journal of Clinical Pharmacology, 1982
It is universally stated that antithyroid drugs are concentrated in human milk and are thus contraindicated during breast-feeding. We recently showed, however, that propylthiouracil (PTU) was not concentrated in milk and a study has now been made of the excretion of another widely used antithyroid drug carbimazole (CMI) in human milk. Methimazole (MMI)
K, Johansen, A N, Andersen, J P, Kampmann, J M, Mølholm Hansen, H B, Mortensen   +4 more
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Pharmacokinetic Properties and Bioavailability of Methimazole

Clinical Pharmacokinetics, 1985
The pharmacokinetics of methimazole following therapeutic doses were studied in healthy subjects, in thyrotoxic and hypothyroid patients before and after treatment to euthyroidism, and in patients with renal or hepatic insufficiency, using a highly sensitive gas chromatographic-mass spectrometric assay.
R, Jansson, B, Lindström, P A, Dahlberg
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Methimazole and Agranulocytosis — Clinical Study

Experimental and Clinical Endocrinology & Diabetes, 2009
The paper deals with agranulocytosis as one of the side effects of methimazole. The analysis of 7 cases allows some conclusions in respect to prevention, early detection and treatment of this rare but serious complication.
U, Tuschy, J, Mühlan
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