Results 161 to 170 of about 9,775 (218)

Methimazole embryopathy: Delineation of the phenotype

American Journal of Medical Genetics Part A, 1999
We report on a further case of congenital anomalies in a child exposed to methimazole during the first trimester of pregnancy (from first to seventh gestational week), and define a specific malformation pattern related to prenatal methimazole exposure and consisting of choanal and esophageal atresia, scalp defects, minor facial anomalies and ...
Maurizio Clementi, Elena Di Gianantonio, I Mammi   +2 more
exaly   +4 more sources

Desensitization to Methimazole

Endocrine Practice, 2021
Thionamides (methimazole and propylthiouracil) have been associated with common side effects, such as rash and pruritus, and rare but serious adverse effects, such as agranulocytosis and hepatotoxicity. Methimazole is usually the preferred thionamide for the treatment of hyperthyroidism if the patient is not planning to conceive or not in the first ...
Alaleh, Mazhari, Mary Ann, Emanuele, Baltazar, Espiritu   +2 more
openaire   +2 more sources

Pharmacokinetics of methimazole in humans

Klinische Wochenschrift, 1985
A newly developed method for extracting and measuring methimazole in biological fluids was used to study the pharmacokinetics of methimazole in two euthyroid and eight hyperthyroid subjects. The volume of distribution approximated total body water; the biological half-life was 2-3 h in euthyroid and about 6 h in hyperthyroid patients.
J H, Hengstmann, H, Hohn
openaire   +2 more sources

TOXICITY OF METHIMAZOLE (TAPAZOLE)

Journal of the American Medical Association, 1954
Toxic manifestations of methimazole therapy have been documented by several investigators.1Skin rashes, agranulocytosis, arthritis, and toxic hepatitis have been reported. We wish to report the case of a patient treated with methimazole in whom a sudden marked neuropathy associated with foot drop developed.
G S, ACCETTA, A O, FITZMORRIS, R F, WETTINGFELD   +2 more
openaire   +2 more sources

Methimazole-Induced Serum Sickness

Acta Clinica Belgica, 1983
SummaryA female patient with multinodular goiter was treated with methimazole (MMI) for thyrotoxicosis. After 3 weeks, she developped sore throat, pruritus, arthralgias, facial oedema and fever. Biological data were suggesting a scrum sickness. To our knowledge, this is the first published case report of MMI-induced serum sickness. Acta Clin Belg.
Van Kuyk, M, Vanlaethem, Yves, Duchateau, Jean, Bonnyns, Marc   +3 more
openaire   +4 more sources

Methimazole Pharmacology in Man: Studies Using a Newly Developed Radioimmunoassay for Methimazole*

The Journal of Clinical Endocrinology & Metabolism, 1984
A RIA for the antithyroid drug methimazole [1-methyl-2-mercaptoimidazole (MMI)] has been developed. A MMI derivative, 5-COOH-MMI, was conjugated to porcine thyroglobulin, and antibodies to the conjugate were raised in rabbits. [35S]MMI was used as the tracer. At a final antibody dilution of 1:100, the assay could detect MMI in amounts as low as 2.5 ng.
D S, Cooper, H H, Bode, B, Nath, V, Saxe, F, Maloof, E C, Ridgway   +5 more
openaire   +2 more sources

Methimazole-Induced Hepatotoxicity

Endocrine Practice, 2002
To present the case of a patient with Graves' hyperthyroidism in whom treatment with methimazole led to severe cholestasis.A detailed case report and an overview of previously published cases of methimazole- and carbimazole-induced hepatotoxicity, found in a MEDLINE search with use of methimazole, carbimazole, thionamides and antithyroid agents as ...
openaire   +2 more sources

Potential Teratogenicity of Methimazole: Exposure of Zebrafish Embryos to Methimazole Causes Similar Developmental Anomalies to Human Methimazole Embryopathy

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
While methimazole (MMI) is widely used in the therapy for hyperthyroidism, several groups have reported that maternal exposure to MMI results in a variety of congenital anomalies, including choanal and esophageal atresia, iridic and retinal coloboma, and delayed neurodevelopment.
Yuta, Komoike, Masato, Matsuoka, Kenjiro, Kosaki   +2 more
openaire   +2 more sources

Methimazole Pharmacology in the Rat: Studies Using a Newly Developed Radioimmunoassay for Methimazole*

Endocrinology, 1984
Methimazole [1-methyl-2-mercaptoimidazole (MMI)] was given to normal male rats in their drinking water in concentrations ranging from 0.0001-0.05% for either 1 week or 1 month. Serum MMI levels in the rats ranged from 0.008-19.6 micrograms/ml, and were similar after 1 week and 1 month of treatment.
D S, Cooper, J D, Kieffer, V, Saxe, H, Mover, F, Maloof, E C, Ridgway   +5 more
openaire   +2 more sources

COMPARISON OF METHIMAZOLE, METHIMAZOLE AND SODIUM IPODATE, AND METHIMAZOLE AND SATURATED SOLUTION OF POTASSIUM IODIDE IN THE EARLY TREATMENT OF HYPERTHYROID GRAVES’DISEASE

Clinical Endocrinology, 1988
SUMMARYWe have evaluated three regimens for the rapid control (10 days’therapy) of thyrotoxicosis in hyperthyroid Graves’disease: methimazole (MMI, 40 mg/ day), MMI and sodium ipodate (MMI + Na Ipodate, 1 g/day and MMI and saturated solution of potassium iodide (MMI + SSKI, 6 drops twice daily).
E, Roti, G, Robuschi, E, Gardini, M, Montermini, M, Salvi, A, Manfredi, A, Gnudi, L E, Braverman   +7 more
openaire   +2 more sources