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[Methimazole versus methimazole and diphosphonates in hyperthyroid and osteoporotic patients].
Minerva endocrinologica, 2005It is well-know that hyperthyroidism is one of the key causes of secondary osteoporosis. High values of thyroid hormones increase the bone mineral turnover speed by promoting osteoclastic and osteoblastic activities. The aim of our study is to evaluate the increase of bone mineral density (BMD) in osteoporotic and hyperthyroid patients treated with ...
LUPOLI GA +9 more
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Mechanisms of Antithyroidal Activity of Methimazole
Journal of Pharmaceutical Sciences, 1966Methimazole produces a significant inhibition of iodide ion absorption by the intact thyroid which may account for the major portion of its antithyroidal action. The principal intrathyroidal effect of methimazole is shown to be due to its reactivity with elemental iodine.
R E, Brock, W F, Head
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The Effects of Methimazole on Haematopoiesis in Mice
Immunopharmacology and Immunotoxicology, 1995The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks.
N K, Mak +4 more
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Scandinavian Journal of Rheumatology, 1990
(1990). Methimazole and Arthritis. Scandinavian Journal of Rheumatology: Vol. 19, No. 5, pp. 385-385.
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(1990). Methimazole and Arthritis. Scandinavian Journal of Rheumatology: Vol. 19, No. 5, pp. 385-385.
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THERAPEUTIC STUDIES IN HYPERTHYROIDISM: METHIMAZOLE
The Journal of Clinical Endocrinology & Metabolism, 1952INTRODUCTION In the last few years many new agents have been presented to the clinician for the treatment of hyperthyroidism. A great deal of experience and the collected reports of many investigators are necessary before the final role of each of these substances can be definitely determined.
H H, STONE, D W, PETIT, P, STARR
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[Interaction of methimazole and quinones. Spectrophotometric determination of methimazole in blood].
Minerva medica, 1983A sensitive method for spectrophotometric determination of methimazole is based on the reaction of this compound with 2,3-dichloro-1,4-naphtoquinone in presence of ammonia. The colour thus formed is stable, reproducible and linear in the range 0,4 to 4 micrograms/ml of methimazole concentration. This method has been employed successfully for estimation
N, Gallo, P, Bianco, R, Tapino, G, Luisi
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Methimazole: An Alternative Route of Administration*
The Journal of Clinical Endocrinology & Metabolism, 1982Methimazole was administered orally and rectally in a single dose of 60 mg to six euthyroid volunteers (three females and three males). Blood levels of methimazole were the same whether administered by the oral or rectal route, with peak levels of 1184 +/- 118 and 1163 +/- 150 (+/-SEM) ng/ml respectively.
N, Nabil, D J, Miner, J M, Amatruda
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Methimazole Drug Allergy: A Possible Solution Using a “Methimazole Solution”
Endocrine Practice, 2021David S, Cooper, N Franklin, Adkinson
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Methimazole-induced Cholestatic Jaundice
Southern Medical Journal, 2004Methimazole is a widely used and generally well-tolerated antithyroid agent. A 43-year-old woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and propranolol (20 mg tid) for treatment of hyperthyroidism. The patient continued treatment for another 4 days after the appearance of jaundice until she finished both ...
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