Results 171 to 180 of about 13,680 (210)

Methimazole-Induced Jaundice

JAMA: The Journal of the American Medical Association, 1973
Unlike some drug-induced hepatitis, about half of the cases of methimazole-induced hepatitis continue for eight to ten weeks after use of the drug is discontinued. If stopping therapy with the drug fails to produce resolution of the process, percutaneous transhepatic cholangiography should be performed.
M G, Fischer, H R, Nayer, A, Miller
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TOXICITY OF METHIMAZOLE (TAPAZOLE)

Journal of the American Medical Association, 1954
Toxic manifestations of methimazole therapy have been documented by several investigators.1Skin rashes, agranulocytosis, arthritis, and toxic hepatitis have been reported. We wish to report the case of a patient treated with methimazole in whom a sudden marked neuropathy associated with foot drop developed.
G S, ACCETTA, A O, FITZMORRIS, R F, WETTINGFELD   +2 more
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Potential Teratogenicity of Methimazole: Exposure of Zebrafish Embryos to Methimazole Causes Similar Developmental Anomalies to Human Methimazole Embryopathy

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
While methimazole (MMI) is widely used in the therapy for hyperthyroidism, several groups have reported that maternal exposure to MMI results in a variety of congenital anomalies, including choanal and esophageal atresia, iridic and retinal coloboma, and delayed neurodevelopment.
Yuta, Komoike, Masato, Matsuoka, Kenjiro, Kosaki   +2 more
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Methimazole Toxicity from High Doses

Annals of Internal Medicine, 1972
Abstract The toxic effects of high-dose methimazole therapy (120 mg/day) were studied in 25 consecutive patients receiving such therapy.
J J, Wiberg, F Q, Nuttall
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Methimazole-induced Cholestatic Jaundice

Southern Medical Journal, 2004
Methimazole is a widely used and generally well-tolerated antithyroid agent. A 43-year-old woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and propranolol (20 mg tid) for treatment of hyperthyroidism. The patient continued treatment for another 4 days after the appearance of jaundice until she finished both ...
openaire   +2 more sources

Methimazole Pharmacology in Man: Studies Using a Newly Developed Radioimmunoassay for Methimazole*

The Journal of Clinical Endocrinology & Metabolism, 1984
A RIA for the antithyroid drug methimazole [1-methyl-2-mercaptoimidazole (MMI)] has been developed. A MMI derivative, 5-COOH-MMI, was conjugated to porcine thyroglobulin, and antibodies to the conjugate were raised in rabbits. [35S]MMI was used as the tracer. At a final antibody dilution of 1:100, the assay could detect MMI in amounts as low as 2.5 ng.
D S, Cooper, H H, Bode, B, Nath, V, Saxe, F, Maloof, E C, Ridgway   +5 more
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Adverse Effects of Prenatal Methimazole Exposure

Obstetrical & Gynecological Survey, 2001
AbstractBackgroundA specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay.MethodsWe prospectively studied the outcome of pregnancy in 241 women counseled by 10 ...
di Gianantonio, E, Schaefer, C, Mastroiacovo, PP, Cournot, MP, Benedicenti, F, Reuvers, M, Occupati, B, Robert, E, Bellemin, B, Addis, A, Arnon, J, Clementi, M   +11 more
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PROPYLTHIOURACIL AND METHIMAZOLE THERAPY

Journal of the American Medical Association, 1952
It is the purpose of this paper to report the results of the use of methimazole ("tapazole") in 45 patients and propylthiouracil in 54 patients in the management of hyperthyroidism at the Indiana University Medical Center and the Indianapolis General Hospital. All these cases were followed by one or more of us.
G W, IRWIN, H D, VAN VACTOR, M S, NORRIS
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Pharmacokinetics of methimazole in humans

Klinische Wochenschrift, 1985
A newly developed method for extracting and measuring methimazole in biological fluids was used to study the pharmacokinetics of methimazole in two euthyroid and eight hyperthyroid subjects. The volume of distribution approximated total body water; the biological half-life was 2-3 h in euthyroid and about 6 h in hyperthyroid patients.
J H, Hengstmann, H, Hohn
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Anti-Inflammatory Action of Methimazole

Pharmacology, 1997
The anti-inflammatory activity of 1-methylimidazole-2-thiol (methimazole), the most widely used antithyroid drug, was investigated. Methimazole had a marked inhibitory action on prostaglandin H synthase (IC50 = 10 mumol/l), inhibiting the peroxidase (IC50 = 330 mumol/l), although the cyclo-oxygenase was slightly activated.
J F, Lagorce, T, Moulard, A, Rousseau, F, Comby, J, Buxeraud, C, Raby   +5 more
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