Results 221 to 230 of about 15,768 (275)

Methimazole-Induced Hepatotoxicity

Endocrine Practice, 2002
To present the case of a patient with Graves' hyperthyroidism in whom treatment with methimazole led to severe cholestasis.A detailed case report and an overview of previously published cases of methimazole- and carbimazole-induced hepatotoxicity, found in a MEDLINE search with use of methimazole, carbimazole, thionamides and antithyroid agents as ...
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Methimazole Pharmacology in Man: Studies Using a Newly Developed Radioimmunoassay for Methimazole*

The Journal of Clinical Endocrinology & Metabolism, 1984
A RIA for the antithyroid drug methimazole [1-methyl-2-mercaptoimidazole (MMI)] has been developed. A MMI derivative, 5-COOH-MMI, was conjugated to porcine thyroglobulin, and antibodies to the conjugate were raised in rabbits. [35S]MMI was used as the tracer. At a final antibody dilution of 1:100, the assay could detect MMI in amounts as low as 2.5 ng.
D S, Cooper, H H, Bode, B, Nath, V, Saxe, F, Maloof, E C, Ridgway   +5 more
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Potential Teratogenicity of Methimazole: Exposure of Zebrafish Embryos to Methimazole Causes Similar Developmental Anomalies to Human Methimazole Embryopathy

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
While methimazole (MMI) is widely used in the therapy for hyperthyroidism, several groups have reported that maternal exposure to MMI results in a variety of congenital anomalies, including choanal and esophageal atresia, iridic and retinal coloboma, and delayed neurodevelopment.
Yuta, Komoike, Masato, Matsuoka, Kenjiro, Kosaki   +2 more
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Methimazole Pharmacology in the Rat: Studies Using a Newly Developed Radioimmunoassay for Methimazole*

Endocrinology, 1984
Methimazole [1-methyl-2-mercaptoimidazole (MMI)] was given to normal male rats in their drinking water in concentrations ranging from 0.0001-0.05% for either 1 week or 1 month. Serum MMI levels in the rats ranged from 0.008-19.6 micrograms/ml, and were similar after 1 week and 1 month of treatment.
D S, Cooper, J D, Kieffer, V, Saxe, H, Mover, F, Maloof, E C, Ridgway   +5 more
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COMPARISON OF METHIMAZOLE, METHIMAZOLE AND SODIUM IPODATE, AND METHIMAZOLE AND SATURATED SOLUTION OF POTASSIUM IODIDE IN THE EARLY TREATMENT OF HYPERTHYROID GRAVES’DISEASE

Clinical Endocrinology, 1988
SUMMARYWe have evaluated three regimens for the rapid control (10 days’therapy) of thyrotoxicosis in hyperthyroid Graves’disease: methimazole (MMI, 40 mg/ day), MMI and sodium ipodate (MMI + Na Ipodate, 1 g/day and MMI and saturated solution of potassium iodide (MMI + SSKI, 6 drops twice daily).
E, Roti, G, Robuschi, E, Gardini, M, Montermini, M, Salvi, A, Manfredi, A, Gnudi, L E, Braverman   +7 more
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[Methimazole versus methimazole and diphosphonates in hyperthyroid and osteoporotic patients].

Minerva endocrinologica, 2005
It is well-know that hyperthyroidism is one of the key causes of secondary osteoporosis. High values of thyroid hormones increase the bone mineral turnover speed by promoting osteoclastic and osteoblastic activities. The aim of our study is to evaluate the increase of bone mineral density (BMD) in osteoporotic and hyperthyroid patients treated with ...
LUPOLI GA, FITTIPALDI MR, FONDERICO F, PANICO A, COLARUSSO S, DI MICCO L, CAVALLO A, COSTA L, PAGLIONE A, LUPOLI, GIOVANNI   +9 more
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Mechanisms of Antithyroidal Activity of Methimazole

Journal of Pharmaceutical Sciences, 1966
Methimazole produces a significant inhibition of iodide ion absorption by the intact thyroid which may account for the major portion of its antithyroidal action. The principal intrathyroidal effect of methimazole is shown to be due to its reactivity with elemental iodine.
R E, Brock, W F, Head
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The Effects of Methimazole on Haematopoiesis in Mice

Immunopharmacology and Immunotoxicology, 1995
The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks.
N K, Mak, W H, Lai, W K, Liu, K N, Leung, M C, Fung   +4 more
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Methimazole-Based Ionic Liquids

The Journal of Organic Chemistry, 2008
The alkylation reaction of 2-mercapto-1-methylimidazole 1a with iodoethane and chlorobutane produced S-alkylmethimazole halides 2a and 2b which were subjected to anion metathesis with two different metal salts (MA) to afford methimazole-based room-temperature ionic liquids 3a, 3b, and 3c in 82%, 85%, and 87% yields, respectively. S-Alkylation giving 2a
Amal I, Siriwardana, Ian R, Crossley, Angel A J, Torriero, Iko M, Burgar, Noel F, Dunlop, Alan M, Bond, Glen B, Deacon, Douglas R, Macfarlane   +7 more
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Methimazole and Arthritis

Scandinavian Journal of Rheumatology, 1990
(1990). Methimazole and Arthritis. Scandinavian Journal of Rheumatology: Vol. 19, No. 5, pp. 385-385.
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