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THERAPEUTIC STUDIES IN HYPERTHYROIDISM: METHIMAZOLE
The Journal of Clinical Endocrinology & Metabolism, 1952INTRODUCTION In the last few years many new agents have been presented to the clinician for the treatment of hyperthyroidism. A great deal of experience and the collected reports of many investigators are necessary before the final role of each of these substances can be definitely determined.
H H, STONE, D W, PETIT, P, STARR
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[Interaction of methimazole and quinones. Spectrophotometric determination of methimazole in blood].
Minerva medica, 1983A sensitive method for spectrophotometric determination of methimazole is based on the reaction of this compound with 2,3-dichloro-1,4-naphtoquinone in presence of ammonia. The colour thus formed is stable, reproducible and linear in the range 0,4 to 4 micrograms/ml of methimazole concentration. This method has been employed successfully for estimation
N, Gallo, P, Bianco, R, Tapino, G, Luisi
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Anti-Inflammatory Action of Methimazole
Pharmacology, 1997The anti-inflammatory activity of 1-methylimidazole-2-thiol (methimazole), the most widely used antithyroid drug, was investigated. Methimazole had a marked inhibitory action on prostaglandin H synthase (IC50 = 10 mumol/l), inhibiting the peroxidase (IC50 = 330 mumol/l), although the cyclo-oxygenase was slightly activated.
J F, Lagorce +5 more
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Methimazole Drug Allergy: A Possible Solution Using a “Methimazole Solution”
Endocrine Practice, 2021David S, Cooper, N Franklin, Adkinson
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Methimazole-induced Cholestatic Jaundice
Southern Medical Journal, 2004Methimazole is a widely used and generally well-tolerated antithyroid agent. A 43-year-old woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) and propranolol (20 mg tid) for treatment of hyperthyroidism. The patient continued treatment for another 4 days after the appearance of jaundice until she finished both ...
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