Carboxy-Methylation of the Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Integrates Methionine Availability with Methionine Addicted Cancer Cell Proliferation [PDF]
BiomoleculesCancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine.
Anna Andronicos +8 more
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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy
iScience, 2022 Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and degree
Jun Yamamoto +12 more
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Antioxidants, 2021 Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and the ...
Mariano Catanesi +11 more
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Effect of methyl donors supplementation on performance, immune responses and anti-oxidant variables in broiler chicken fed diet without supplemental methionine [PDF]
Animal Bioscience, 2022 Objective Methionine (Met) is involved in methyl group transfer besides protein synthesis. As the availability is limited and cost is high for synthetic Met, reductions in its inclusion in broiler diet may be possible by supplementing the low Met diets ...
Venkata Rama Rao Savaram +4 more
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Redox Report, 2023 Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park +2 more
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Sensing and Signaling of Methionine Metabolism
Metabolites, 2021 Availability of the amino acid methionine shows remarkable effects on the physiology of individual cells and whole organisms. For example, most cancer cells, but not normal cells, are hyper dependent on high flux through metabolic pathways connected to ...
Linda Lauinger, Peter Kaiser
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Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria. [PDF]
Proc Natl Acad Sci U S AMausz MA +7 more
europepmc +3 more sources
Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence. [PDF]
, 2020 CBS deficient individuals undergoing betaine supplementation without sufficient dietary methionine restriction can develop severe hypermethioninemia and brain edema. Brain edema has also been observed in individuals with severe hypermethioninemia without
Barea, Jaime J +10 more
core +1 more source
4006 Methionine Dependence in Cancer: From Metabolic Phenotype to Therapy
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: Methionine dependence was described 45 years ago as an increased reliance on an exogenous supply of the essential amino acid methionine in most cancer cells compared to normal cells. Methionine depletion, using either synthetic diets or
Isabelle Miousse
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An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. [PDF]
PLoS Computational Biology, 2008 Methionine (Met) is an essential amino acid that is needed for the synthesis of S-adenosylmethionine (AdoMet), the major biological methylating agent.
Tatyana K Korendyaseva +6 more
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