Results 1 to 10 of about 531,866 (340)

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

iScience, 2022
Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and degree
Jun Yamamoto, Sachiko Inubushi, Qinghong Han, Yoshihiko Tashiro, Norihiko Sugisawa, Kazuyuki Hamada, Yusuke Aoki, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Steven G. Clarke, Itaru Endo, Robert M. Hoffman   +12 more
doaj   +1 more source

Effect of methyl donors supplementation on performance, immune responses and anti-oxidant variables in broiler chicken fed diet without supplemental methionine [PDF]

Animal Bioscience, 2022
Objective Methionine (Met) is involved in methyl group transfer besides protein synthesis. As the availability is limited and cost is high for synthetic Met, reductions in its inclusion in broiler diet may be possible by supplementing the low Met diets ...
Venkata Rama Rao Savaram, Venkata Lakshmi Narasimha Raju Mantena, Prakash Bhukya, Shyam Sunder Paul, Nagalakshmi Devanaboyina   +4 more
doaj   +1 more source

L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson’s Disease

Antioxidants, 2021
Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and the ...
Mariano Catanesi, Laura Brandolini, Michele d’Angelo, Elisabetta Benedetti, Maria Grazia Tupone, Margherita Alfonsetti, Enrico Cabri, Daniela Iaconis, Maddalena Fratelli, Annamaria Cimini, Vanessa Castelli, Marcello Allegretti   +11 more
doaj   +1 more source

Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases

Redox Report, 2023
Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park, José A. Trujillo-Hernandez, Rodney L. Levine   +2 more
doaj   +1 more source

Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence. [PDF]

, 2020
CBS deficient individuals undergoing betaine supplementation without sufficient dietary methionine restriction can develop severe hypermethioninemia and brain edema. Brain edema has also been observed in individuals with severe hypermethioninemia without
Barea, Jaime J, Barshop, Bruce A, Benoist, Jean-Francois, Blom, Henk J, Das, Anibh M, Feigenbaum, Annette, Fletcher, Janice, Scheffner, Thomas, Schwahn, Bernd C, Stepman, Hedwig, Verloo, Peter   +10 more
core   +1 more source

4006 Methionine Dependence in Cancer: From Metabolic Phenotype to Therapy

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Methionine dependence was described 45 years ago as an increased reliance on an exogenous supply of the essential amino acid methionine in most cancer cells compared to normal cells. Methionine depletion, using either synthetic diets or
Isabelle Miousse
doaj   +1 more source

Roles of sulfur-containing amino acids in gastrointestinal physiology and pathophysiology [PDF]

Vojnosanitetski Pregled, 2021
nema
Todorović Dušan D., Stojanović Marija T., Šćepanović Ljiljana G., Mitrović Dušan M., Šćepanović Vuk D., Šćepanović Radomir D., Ilić Slobodan G., Šćepanović Teja N., Đurić Dragan M.   +8 more
doaj   +1 more source

The Level of Methionine Residues in Storage Proteins Is the Main Limiting Factor of Protein-Bound-Methionine Accumulation in Arabidopsis Seeds

Frontiers in Plant Science, 2020
The low level of methionine, an essential sulfur-containing amino acid, limits the nutritional quality of seeds. Two main factors can control the level of protein-bound methionine: the level of free methionine that limits protein accumulation and the ...
Aiswarya Girija, David Shotan, David Shotan, Yael Hacham, Yael Hacham, Rachel Amir, Rachel Amir   +6 more
doaj   +1 more source

Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs. [PDF]

, 2020
The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described.
Deming, Timothy J, Gharakhanian, Eric G, Negri, Graciela E   +2 more
core   +1 more source

High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive Solutions for Blood Storage

Frontiers in Physiology, 2022
Red blood cell transfusion is a life-saving intervention, and storage is a logistic necessity to make ~110 million units available for transfusion every year worldwide. However, storage in the blood bank is associated with a progressive metabolic decline,
Travis Nemkov, Travis Nemkov, Tatsuro Yoshida, Maria Nikulina, Angelo D’Alessandro, Angelo D’Alessandro   +5 more
doaj   +1 more source