Results 81 to 90 of about 607,306 (389)

Genome-Wide Association Study and Genomic Selection for Proteinogenic Methionine in Soybean Seeds

Frontiers in Plant Science, 2022
Soybean [Glycine max (L.) Merr.] seeds have an amino acid profile that provides excellent viability as a food and feed protein source. However, low concentrations of an essential amino acid, methionine, limit the nutritional utility of soybean protein ...
William M. Singer, Zachary Shea, Dajun Yu, Haibo Huang, M. A. Rouf Mian, Chao Shang, Maria L. Rosso, Qijan J. Song, Bo Zhang   +8 more
doaj   +1 more source

Methionine in proteins: The Cinderella of the proteinogenic amino acids

Protein Science, 2019
Methionine in proteins, apart from its role in the initiation of translation, is assumed to play a simple structural role in the hydrophobic core, in a similar way to other hydrophobic amino acids such as leucine, isoleucine, and valine.
J. Aledo
semanticscholar   +1 more source

Design of an Antifungal Methionine Inhibitor Not Antagonized by Methionine.

Biological and Pharmaceutical Bulletin, 1995
Only a few biosynthetic pathways in fungal cells have been used as antifungal targets. Therefore, the number of antifungals has been limited, and a cross-drug resistance among them has emerged in the therapy of mycoses. Under such circumstances, the identification of an antifungal with a new mode of action is highly desirable.
Tomoko Kamiyama, Mutsumi Yamamoto, Toshihiko Fujii, Mikio Arisawa, Yuhko Aoki, Jun Ohwada   +5 more
openaire   +4 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]

, 2014
The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa, Bill, Markus, Brisson, Vanessa L, Conrad, Mark E, Feng, Xueyang, Men, Yujie, Tang, Yinjie J, Yi, Shan, Zhuang, Wei-Qin   +8 more
core   +1 more source

Antigen receptor control of methionine metabolism in T cells

bioRxiv, 2018
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation.
Linda V. Sinclair, Andrew J. M. Howden, A. Brenes, Laura Spinelli, J. Hukelmann, A. Macintyre, Xiaojing Liu, Sarah Thomson, P. Taylor, J. Rathmell, J. Locasale, A. Lamond, D. Cantrell   +12 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Metabolism and Endocrine Disorders: What Wnt Wrong?

Frontiers in Endocrinology, 2022
A fundamental question in cell biology underlies how nutrients are regenerated to maintain and renew tissues. Physiologically, the canonical Wnt signaling is a vital pathway for cell growth, tissue remodeling, and organ formation; pathologically, Wnt ...
Carolina N. Franco, May M. Noe, Lauren V. Albrecht, Lauren V. Albrecht   +3 more
doaj   +1 more source

The importance of methionine metabolism

eLife, 2019
T helper cells import the amino acid methionine to synthesize new proteins and to provide the methyl groups needed for the methylation of RNA and DNA that drives T cell proliferation and differentiation.
Ramon I Klein Geltink, Erika L Pearce
openaire   +5 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source