Results 91 to 100 of about 3,813 (143)

Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer

Nature Communications
Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-indifferent ...
Alessia Cacciatore, Dheeraj Shinde, Carola Musumeci, Giada Sandrini, Luca Guarrera, Domenico Albino, Gianluca Civenni, Elisa Storelli, Simone Mosole, Elisa Federici, Alessio Fusina, Marta Iozzo, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Marco Bolis, Carlo V. Catapano, Giuseppina M. Carbone   +17 more
doaj   +1 more source

Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration. [PDF]

FASEB J, 2021
Chen L, Liu X, Zhou H, Li G, Huang F, Zhang J, Xia T, Lei W, Zhao J, Li C, Chen M.   +10 more
europepmc   +1 more source

Folding of Dimeric Methionine Adenosyltransferase III [PDF]

Journal of Biological Chemistry, 2002
Manuel M. Sánchez del Pino, Isabel Pérez-Mato, José M. Mato, Fernando J. Corrales, Jesús M. Sanz   +4 more
openaire   +1 more source

Methionine Adenosyltransferase Deficiency [PDF]

, 2020
openaire   +1 more source

Hysteretic Behavior of Methionine Adenosyltransferase III [PDF]

Journal of Biological Chemistry, 2000
Manuel M. Sánchez del Pino, Fernando J. Corrales, José M. Mato   +2 more
openaire   +1 more source

Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias

Cell Death Discovery
Polyamines, namely putrescine, spermidine and spermine, are involved in multiple molecular pathways through their ability to bind nucleic acids and modulate protein stability.
Francesca Pirini, Anna Ferrari, Mouna Jandoubi, Irene Azzali, Davide Angeli, Rossana Mondrone, Chiara Bracci, Francesca Ruggieri, Giovanni Martinelli, Giorgia Simonetti   +9 more
doaj   +1 more source

Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes. [PDF]

ACS Chem Biol, 2020
Huber TD, Clinger JA, Liu Y, Xu W, Miller MD, Phillips GN, Thorson JS.   +6 more
europepmc   +1 more source

Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. [PDF]

Hepatology, 2020
Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC.   +18 more
europepmc   +1 more source

Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p. [PDF]

Bioengineered, 2020
Chen H, Gu B, Zhao X, Zhao Y, Huo S, Liu X, Lu H.   +6 more
europepmc   +1 more source

Tumor-associated neutrophils drive liver-specific metastatic progression in breast cancer through methionine metabolism mediated by methionine adenosyltransferase II alpha. [PDF]

Transl Cancer Res
Huang L, Zhen S, Wang Q, Sun Y, Ji T, Chen R, Wang J, Zhu Q, Xu D, Zha X.   +9 more
europepmc   +1 more source