Results 121 to 130 of about 4,135 (162)

Abnormal methionine adenosyltransferase in hypermethioninemia

Biochemical and Biophysical Research Communications, 1975
Abstract Methionine adenosyltransferase activity was reduced in liver from a child with hypermethioninemia. Kinetic studies demonstrated a pattern suggesting negative cooperativity for enzyme derived from rat and human liver. The patient's enzyme was characterized by a decrease in the apparent maximum Km(met).
J D, Finkelstein, W E, Kyle, J J, Martin
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Methionine adenosyltransferase: Structure and function

Pharmacology & Therapeutics, 1993
Methionine adenosyltransferase (MAT), a key enzyme in metabolism, catalyzes the synthesis of one of the most important and pivotal biological molecules, S-adenosyl-methionine. In every organism studied thus far, MAT exists in multiple forms; most are encoded by related, but distinct genes.
M, Kotb, A M, Geller
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Inhibition of Methionine Adenosyltransferase by the Polyamines

Archives of Biochemistry and Biophysics, 1997
The effect of the polyamines, putrescine, spermine, and spermidine, on the activity of extrahepatic methionine adenosyltransferase (MAT II) was studied. The polyamines inhibited MAT II activity at concentrations equal to or greater than 5 mm. Combinations of polyamines were more effective than individual polyamines in inhibiting MAT activity; maximum ...
A M, Geller, H L, Legros, K, Wherry, M Y, Kotb   +3 more
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Interaction of liver methionine adenosyltransferase with hydroxyl radical

The FASEB Journal, 1997
Liver methionine adenosyltransferase (MAT) plays a critical role in the metabolism of methionine converting this amino acid, in the presence of ATP, into S‐adenosylmethionine. Here we report that hydrogen peroxide (H 2 O 2 ), via generation of hydroxyl ...
Corrales, F.J. (Fernando José), Ruiz, F.A. (Félix A.), An, W.G. (Won G.), Sanchez-Gongora, E. (E.), Mingorance, J. (J.), Mato, J.M. (José María)   +5 more
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Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases

Biochemical Pharmacology, 1983
Two isozymes of ATP:L-methionine S-adenosyltransferase (MAT) were fractionated from rat Novikoff solid hepatoma. Their Km values for L-methionine and/or their inhibition constants for various L-methionine analogues were significantly different from the kinetic constants obtained for three isozymes fractionated from normal rat liver.
J B, Lombardini, J R, Sufrin
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Methionine adenosyltransferase in man: Evidence for multiple forms

Biochemical Medicine, 1979
Abstract Optimum conditions are presented for the assay of methionine adenosyltransferase (ATP: l -methionine S -adenosyltransferase, EC 2.5.1.6) in human erythrocytes and in human cultured fibroblasts and long-term lymphoid cell lines. The enzymes are similar in having an acidic pH optimum (5.2–5.7) and in being inhibited by more than 10 m m Mg 2+
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Leishmania donovani methionine adenosyltransferase

2002
Junta de Castilla y ...
Pérez Pertejo, Maria Yolanda, Reguera Torres, Rosa María, Villa, Hector, García Estrada, Carlos, Balaña Fouce, Rafael, Pajares, Maria A., Ordóñez, David   +6 more
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Molecular genetics of hepatic methionine adenosyltransferase deficiency

Pharmacology & Therapeutics, 2000
Hepatic methionine adenosyltransferase (MAT) deficiency is caused by mutations in the human MAT1A gene that abolish or reduce hepatic MAT activity that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. This genetic disorder is characterized by isolated persistent hypermethioninemia in the absence of cystathionine beta-synthase ...
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Methionine adenosyltransferase and S-adenosylmethionine in the developing rat lens

Experimental Eye Research, 1988
Methionine adenosyltransferase (MAT) activity, and the concentration of its reaction product, S-adenosylmethionine (AdoMet), were measured in the lenses of rats of different ages; ranging from 1 day of age to over 1 yr. The highest specific activity of MAT was found in the lenses of the one day old rats (sp. ac. 0.327 units/mg-1 protein).
A M, Geller, M Y, Kotb, H M, Jernigan, N M, Kredich   +3 more
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Erythrocyte and brain methionine adenosyltransferase activities in patients with schizophrenia

Journal of Neural Transmission, 1998
The activity of methionine adenosyltransferase (MAT) was investigated in erythrocytes and postmortem brain specimens (cortex gyrus frontalis, hippocampus and thalamus) of patients with schizophrenia treated with neuroleptics. In comparison with the control group, abnormally low values of MAT Vmax and an increased MAT affinity towards methionine (lower ...
C, Gomes-Trolin, M, Yassin, C G, Gottfries, B, Regland, B, Grenfeldt, J, Hallman, J, Prince, L, Oreland   +7 more
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