Results 131 to 140 of about 4,135 (162)

Methionine adenosyltransferase activity in cultured cells and in human tissues

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991
We have investigated methionine adenosyltransferase activity (MAT) in extracts of a variety of normal and malignant human tissues and cultured cell lines. MAT activity assayed from 17 different cultured cell lines varied to a great extent. Ramos (human, Burkitt's lymphoma) and EL4 (mouse, T cell lymphoma) cells showed MAT activity near 300 pmol/mg per ...
K, Akerman, K, Karkola, O, Kajander
openaire   +2 more sources

Changes in methionine adenosyltransferase during liver regeneration in the rat

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1998
Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. We previously showed that MAT2A expression was associated with more rapid cell growth.
Z Z, Huang, Z, Mao, J, Cai, S C, Lu
openaire   +2 more sources

Methionine adenosyltransferase and S‐adenosylmethionine in alcoholic liver disease

Journal of Gastroenterology and Hepatology, 2006
AbstractMethionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of the principal methyl donor S‐adenosylmethionine (SAMe). Studies in the past decade have shown that SAMe is not only a methyl donor, but also a key metabolite that regulates hepatocyte growth, death and differentiation.
Shelly C, Lu, M Luz, Martínez-Chantar, José M, Mato   +2 more
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Methionine metabolism in BHK cells: The regulation of methionine adenosyltransferase

Journal of Cellular Physiology, 1977
AbstractThe regulation of methionine adenosyltransferase (MAT), an enzyme involved in SAM Abbreviations: DEAE cellulose, diethylaminoethyl cellulose; Hydroxo‐B1,2, (5.6‐dimethylbenzimidazolyl) hydroxo‐cobamide; MAMP, methioninol AMP; MAT, ATP: L‐methionine S‐adenosyltransferase; MTS, methionly tRNA synthetase; SAM, S‐adenosyl L‐methionine; tRNAmet, L ...
openaire   +4 more sources

Methionine adenosyltransferase

Analytical Biochemistry, 1972
S. Matthysse, R.J. Baldessarini, M. Vogt
openaire   +1 more source

Methionine adenosyltransferase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Topology of human methionine S-adenosyltransferase

2006
Insights into the three-dimensional (3D) structure of the enzyme, Methionine S-adenosyltransferase (MAT), call throw light on its role in humans and help in evolving selectivity attributes of inhibitors targeted at bacterial MAT. We report here a 3D-model of human MAT, using the X-ray structure of MAT from the rat as a template, by comparative protein ...
Khedkar, Santosh A., Malde, Alpeshkumar K., Coutinho, Evans C.   +2 more
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Analogues of Methionine as Substrates and Inhibitors of the Methionine Adenosyltransferase Reaction

Molecular Pharmacology, 1970
J.B. LOMBARDINI, A.W. COULTER, PAUL TALALAY   +2 more
openaire   +1 more source

Identification of methionine adenosyltransferase with high diastereoselectivity for biocatalytic synthesis of (S)-S-adenosyl-l-methionine and exploring its relationship with fluorinated biosynthetic pathway

Enzyme and Microbial Technology, 2021
Long Ma, Siyu Ren, Xinkuan Cheng
exaly  

Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer

Alcohol, 2005
José Mato, Shelly Lu
exaly