Results 11 to 20 of about 764,898 (194)
Antioxidants, 2023 A major contributor to dementia seen in aging is Alzheimer’s disease (AD). Amyloid beta (Aβ), a main component of senile plaques (SPs) in AD, induces neuronal death through damage to cellular organelles and structures, caused by oxidation of important molecules such as proteins by reactive oxygen species (ROS).
Sanjana Chandran, David Binninger
openaire +4 more sources
A study into the cobalamin-dependent methionine synthase reactivation mechanism in corynebacterium glutamicum [PDF]
, 2009 PhDMethionine is one of the seven essential amino-acids for humans and is also used in feed supplements, predominantly for poultry and felines. Thus there is commercial interest in producing this nutrient. The final step in the biological synthesis of
Burton-Smith, Raymond Nathaniel
core +4 more sources
Methionine oxidation and reduction in proteins [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Cysteine and methionine are the two sulfur containing amino acids in proteins. While the roles of protein-bound cysteinyl residues as endogenous antioxidants are well appreciated, those of methionine remain largely unexplored.We summarize the key roles of methionine residues in proteins.Recent studies establish that cysteine and methionine have ...
Geumsoo, Kim +2 more
openaire +2 more sources
Regulated methionine oxidation by monooxygenases [PDF]
Free Radical Biology and Medicine, 2017 Protein function can be regulated via post-translational modifications by numerous enzymatic and non-enzymatic mechanisms, including oxidation of cysteine and methionine residues. Redox-dependent regulatory mechanisms have been identified for nearly every cellular process, but the major paradigm has been that cellular components are oxidized (damaged ...
Bruno, Manta, Vadim N, Gladyshev
openaire +2 more sources
Methionine oxidation within the prion protein [PDF]
Prion, 2020 Prion diseases are characterized by the self-templated misfolding of the cellular prion protein (PrPC) into infectious aggregates (PrPSc). The detailed molecular basis of the misfolding and aggregation of PrPC remains incompletely understood. It is believed that the transient misfolding of PrPC into partially structured intermediates precedes the ...
John Bettinger, Sina Ghaemmaghami
openaire +2 more sources
Redox proteomics of protein-bound methionine oxidation [PDF]
, 2011 We here present a new method to measure the degree of protein-bound methionine sulfoxide formation at a proteome-wide scale. In human Jurkat cells that were stressed with hydrogen peroxide, over 2000 oxidation-sensitive methionines in more than 1600 ...
Ghesquière, Bart +19 more
core +1 more source
KINETIC INVESTIGATIONS OF THE IODINE OXIDATION OF METHIONINE AND ITS DERIVATIVES.
, 1981 KINETIC INVESTIGATIONS OF THE IODINE OXIDATION OF METHIONINE AND ITS ...
LI-SHAN. HSIEH (7990139)
core +4 more sources
Oxidation of Methionine by Human Polymorphonuclear Leukocytes [PDF]
Journal of Clinical Investigation, 1980 Studies of the photosensitized oxidation have demonstrated that photodynamic oxidation of methionine is mediated by singlet oxygen ((1)O(2)). In this study, we demonstrated that phagocytosing human polymorphonuclear leukocytes (PMN), but not resting PMN, oxidized both intracellular and extracellular methionine to methionine sulfoxide. N-ethylmaleimide,
M F, Tsan, J W, Chen
openaire +2 more sources
Methionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry
Journal of the American Society for Mass Spectrometry, 2023 Abstract Post-translational oxidation of methionine residues can destabilize proteins or modify their functions. Although levels of methionine oxidation can provide important information regarding the structural integrity and regulation of proteins, their quantitation is often challenging as analytical procedures in and of themselves ...
Margaret Hoare +5 more
openaire +2 more sources
Analysis of Methionine/Selenomethionine Oxidation and Methionine Sulfoxide Reductase Function Using Methionine-Rich Proteins and Antibodies against Their Oxidized Forms [PDF]
Biochemistry, 2008 Methionine (Met) residues are present in most proteins. However, this sulfur-containing amino acid is highly susceptible to oxidation. In cells, the resulting Met sulfoxides are reduced back to Met by stereospecific reductases MsrA and MsrB. Reversible Met oxidation occurs even in the absence of stress, is elevated during aging and disease, but is ...
Dung Tien, Le +7 more
openaire +2 more sources