Methionine Sulfoxide Reductases of Archaea [PDF]
Antioxidants, 2018 Methionine sulfoxide reductases are found in all domains of life and are important in reversing the oxidative damage of the free and protein forms of methionine, a sulfur containing amino acid particularly sensitive to reactive oxygen species (ROS ...
Julie A Maupin-Furlow
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The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function [PDF]
Antioxidants, 2018 Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Bertrand Friguet, Isabelle Petropoulos
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Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling [PDF]
Antioxidants, 2018 Oxidation of methionine (Met) leads to the formation of two S- and R-diastereoisomers of Met sulfoxide (MetO) that are reduced back to Met by methionine sulfoxide reductases (MSRs), A and B, respectively.
Pascal Rey, Lionel Tarrago
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Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases [PDF]
Redox Report, 2023 Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park +2 more
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Methionine Sulfoxide Reductases Suppress the Formation of the [PSI+] Prion and Protein Aggregation in Yeast [PDF]
Antioxidants, 2023 Prions are self-propagating, misfolded forms of proteins associated with various neurodegenerative diseases in mammals and heritable traits in yeast. How prions form spontaneously into infectious amyloid-like structures without underlying genetic changes
Jana Schepers +3 more
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Methionine Sulfoxide Reductases Contribute to Anaerobic Fermentative Metabolism in Bacillus cereus [PDF]
Antioxidants, 2021 Reversible oxidation of methionine to methionine sulfoxide (Met(O)) is a common posttranslational modification occurring on proteins in all organisms under oxic conditions.
Catherine Duport +4 more
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Role of Oxidative Stress, Methionine Oxidation and Methionine Sulfoxide Reductases (MSR) in Alzheimer’s Disease [PDF]
Antioxidants, 2023 A major contributor to dementia seen in aging is Alzheimer’s disease (AD). Amyloid beta (Aβ), a main component of senile plaques (SPs) in AD, induces neuronal death through damage to cellular organelles and structures, caused by oxidation of important ...
Sanjana Chandran, David Binninger
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Protection of Membrane Contact Protein by the Methionine Sulfoxide Reductases [PDF]
ContactIn this News and Views, I discuss our recent publication that established how steroidogenic acute regulatory-related lipid transfer domain-3 (STARD3), a membrane contact protein situated at lysosomal membranes, plays a role in the detoxification of ...
Jung Mi Lim
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Methionine sulfoxide reductases are essential for virulence of Salmonella typhimurium. [PDF]
PLoS ONE, 2011 Production of reactive oxygen species represents a fundamental innate defense against microbes in a diversity of host organisms. Oxidative stress, amongst others, converts peptidyl and free methionine to a mixture of methionine-S- (Met-S-SO) and ...
Luisa A Denkel +7 more
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Significance of four methionine sulfoxide reductases in Staphylococcus aureus. [PDF]
PLoS ONE, 2015 Staphylococcus aureus is a major human pathogen and emergence of antibiotic resistance in clinical staphylococcal isolates raises concerns about our ability to control these infections.
Vineet K Singh +7 more
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