In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster [PDF]
Antioxidants, 2018 The deleterious alteration of protein structure and function due to the oxidation of methionine residues has been studied extensively in age-associated neurodegenerative disorders such as Alzheimer’s and Parkinson’s Disease.
Lindsay Bruce +7 more
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The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases [PDF]
Antioxidants, 2018 This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals.
Beichen Jiang, Jackob Moskovitz
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Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis [PDF]
Antioxidants, 2018 Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection.
Sandrine Boschi-Muller
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Methionine Residues in Exoproteins and Their Recycling by Methionine Sulfoxide Reductase AB Serve as an Antioxidant Strategy in Bacillus cereus [PDF]
Frontiers in Microbiology, 2017 During aerobic respiratory growth, Bacillus cereus is exposed to continuously reactive oxidant, produced by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS).
Jean-Paul Madeira +4 more
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Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA) [PDF]
Scientific Reports, 2022 Methionine restriction (MR) extends lifespan and improves several markers of health in rodents. However, the proximate mechanisms of MR on these physiological benefits have not been fully elucidated.
Kevin M. Thyne, Adam B. Salmon
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Antioxidants, 2018 Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Sofia Lourenço dos Santos +2 more
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Methionine Sulfoxide Reductase B Regulates the Activity of Ascorbate Peroxidase of Banana Fruit [PDF]
Antioxidants, 2021 Ascorbate peroxidase (APX) is a key antioxidant enzyme that is involved in diverse developmental and physiological process and stress responses by scavenging H2O2 in plants. APX itself is also subjected to multiple posttranslational modifications (PTMs).
Lu Xiao +6 more
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Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in
mBio, 2017 Methionine sulfoxide reductase A (MsrA) is an antioxidant enzyme found in all domains of life that catalyzes the reduction of methionine-S-sulfoxide (MSO) to methionine in proteins and free amino acids.
Xian Fu +7 more
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Characterization and mechanism investigation of salt-activated methionine sulfoxide reductase A from halophiles [PDF]
iScienceSummary: Halophiles, thriving in harsh saline environments, capture scientific interest due to their remarkable ability to prosper under extreme salinity.
Shihuan Zhou +9 more
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Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus [PDF]
Diabetology & Metabolic SyndromeDiabetes mellitus (DM) is a progressive, chronic metabolic disorder characterized by high oxidative stress, which can lead to cardiac damage. Methionine sulfoxylation (MetO) of proteins by excessive reactive oxygen species (ROS) can impair the basic ...
Seung Hee Lee +13 more
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