Selenium and the Methionine Sulfoxide Reductase System [PDF]
Molecules, 2009 Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines.
Jackob Moskovitz, Derek B. Oien
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The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate [PDF]
Frontiers in Immunology, 2019 Control of the sexually transmitted infection gonorrhea is a major public health challenge, due to the recent emergence of multidrug resistant strains of Neisseria gonorrhoeae, and there is an urgent need for novel therapies or a vaccine to prevent ...
Freda E.-C. Jen +4 more
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Methionine sulfoxide reductases are essential for virulence of Salmonella typhimurium. [PDF]
PLoS ONE, 2011 Production of reactive oxygen species represents a fundamental innate defense against microbes in a diversity of host organisms. Oxidative stress, amongst others, converts peptidyl and free methionine to a mixture of methionine-S- (Met-S-SO) and ...
Luisa A Denkel +7 more
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Reduction of Protein Bound Methionine Sulfoxide by a Periplasmic Dimethyl Sulfoxide Reductase [PDF]
Antioxidants, 2020 In proteins, methionine (Met) can be oxidized into Met sulfoxide (MetO). The ubiquitous methionine sulfoxide reductases (Msr) A and B are thiol-oxidoreductases reducing MetO.
Lionel Tarrago +9 more
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Methionine sulfoxide reductase A is a stereospecific methionine oxidase [PDF]
Proceedings of the National Academy of Sciences, 2011 Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide
Zheng You +3 more
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Distribution of methionine sulfoxide reductases in fungi and conservation of the freemethionine-R-sulfoxide reductase in multicellular eukaryotes [PDF]
Free Radical Biology and Medicine, 2021 Methionine, either as a free amino acid or included in proteins, can be oxidized into methionine sulfoxide (MetO), which exists as R and S diastereomers.
Tarrago, Lionel +2 more
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Redox Report, 2023 Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park +2 more
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Glutathione- and glutaredoxin-dependent reduction of methionine sulfoxide reductase A [PDF]
FEBS Letters, 2012 A natural fusion occurring between two tandemly repeated glutaredoxin (Grx) modules and a methionine sulfoxide reductase A (MsrA) has been detected in Gracilaria gracilis.
Couturier, Jérémy +3 more
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Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. [PDF]
PLoS ONE, 2013 Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological conditions. Organisms evolved two distinct methionine sulfoxide reductase families (MSRA & MSRB) to repair oxidized methionine residues.
Dung Tien Le +9 more
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Investigation of salt-bridge interactions underlying salt activation of halophilic methionine sulfoxide reductase A [PDF]
Frontiers in MicrobiologyIntroductionHalophilic microorganisms inhabit hypersaline environments where sustained ionic stress challenges protein structure and function, making salt-responsive enzymes important for cellular fitness.
Shuhong Chen +8 more
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