The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases [PDF]
Antioxidants, 2018 This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals.
Jackob Moskovitz
exaly +4 more sources
In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster [PDF]
Antioxidants, 2018 The deleterious alteration of protein structure and function due to the oxidation of methionine residues has been studied extensively in age-associated neurodegenerative disorders such as Alzheimer’s and Parkinson’s Disease.
Lindsay Bruce +7 more
doaj +2 more sources
Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA) [PDF]
Scientific Reports, 2022 Methionine restriction (MR) extends lifespan and improves several markers of health in rodents. However, the proximate mechanisms of MR on these physiological benefits have not been fully elucidated.
Kevin M. Thyne, Adam B. Salmon
doaj +2 more sources
The Fused Methionine Sulfoxide Reductase MsrAB Promotes Oxidative Stress Defense and Bacterial Virulence in Fusobacterium nucleatum [PDF]
mBio, 2022 Fusobacterium nucleatum, an anaerobic Gram-negative bacterium frequently found in the human oral cavity and some extra-oral sites, is implicated in several important diseases: periodontitis, adverse pregnancy outcomes, and colorectal cancer. To date, how
Matthew Scheible +12 more
doaj +2 more sources
Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis [PDF]
Antioxidants, 2018 Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection.
Sandrine Boschi-Muller
doaj +2 more sources
Structural Insights into a Bifunctional Peptide Methionine Sulfoxide Reductase MsrA/B Fusion Protein from Helicobacter pylori [PDF]
Antioxidants, 2021 Methionine sulfoxide reductase (Msr) is a family of enzymes that reduces oxidized methionine and plays an important role in the survival of bacteria under oxidative stress conditions.
Sulhee Kim +6 more
doaj +2 more sources
Antioxidants, 2018 Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Bertrand Friguet, Isabelle Petropoulos
exaly +3 more sources
Characterization and mechanism investigation of salt-activated methionine sulfoxide reductase A from halophiles [PDF]
iScienceSummary: Halophiles, thriving in harsh saline environments, capture scientific interest due to their remarkable ability to prosper under extreme salinity.
Shihuan Zhou +9 more
doaj +2 more sources
The Peptide Methionine Sulfoxide Reductase (MsrAB) of Haemophilus influenzae Repairs Oxidatively Damaged Outer Membrane and Periplasmic Proteins Involved in Nutrient Acquisition and Virulence [PDF]
Antioxidants, 2022 Sulfoxide-damage repair mechanisms are emerging as essential for the virulence of bacterial pathogens, and in the human respiratory pathogen Haemophilus influenzae the periplasmic MsrAB peptide methionine sulfoxide reductase is necessary for resistance ...
Marufa Nasreen +3 more
doaj +2 more sources
Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in
mBio, 2017 Methionine sulfoxide reductase A (MsrA) is an antioxidant enzyme found in all domains of life that catalyzes the reduction of methionine-S-sulfoxide (MSO) to methionine in proteins and free amino acids.
Xian Fu +7 more
doaj +2 more sources