Investigation of salt-bridge interactions underlying salt activation of halophilic methionine sulfoxide reductase A [PDF]
Frontiers in MicrobiologyIntroductionHalophilic microorganisms inhabit hypersaline environments where sustained ionic stress challenges protein structure and function, making salt-responsive enzymes important for cellular fitness.
Shuhong Chen +8 more
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Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction [PDF]
Redox Biology, 2021 Methionine sulfoxide reductase A (MsrA) is a widely expressed antioxidant enzyme that counteracts oxidative protein damage and contributes to protein regulation by reversing oxidation of protein methionine residues.
Francesca Mazzoni +4 more
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The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function [PDF]
Antioxidants, 2020 Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function.
Beichen Jiang +5 more
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Methionine Residues in Exoproteins and Their Recycling by Methionine Sulfoxide Reductase AB Serve as an Antioxidant Strategy in Bacillus cereus [PDF]
Frontiers in Microbiology, 2017 During aerobic respiratory growth, Bacillus cereus is exposed to continuously reactive oxidant, produced by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS).
Jean-Paul Madeira +4 more
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Methionine biosynthetic genes and methionine sulfoxide reductase A are required for Rhizoctonia solani AG1‐IA to cause sheath blight disease in rice [PDF]
Microbial BiotechnologyRhizoctonia solani is a polyphagous necrotrophic fungal pathogen that causes sheath blight disease in rice. It deploys effector molecules as well as carbohydrate‐active enzymes and enhances the production of reactive oxygen species for killing host ...
Joyati Das +4 more
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The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate [PDF]
Frontiers in Immunology, 2019 Control of the sexually transmitted infection gonorrhea is a major public health challenge, due to the recent emergence of multidrug resistant strains of Neisseria gonorrhoeae, and there is an urgent need for novel therapies or a vaccine to prevent ...
Freda E.-C. Jen +4 more
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Role of ClpX and MsrA/B in the Oxidative and Cell Wall Stress Response in Bacillus anthracis Sterne
MicrobiologyOpenClpX functions as a component of the ClpXP protease, a conserved intracellular protease that regulates protein turnover, stress responses, and virulence in multiple bacterial species.
Aeron B. Pennington +5 more
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Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus [PDF]
Diabetology & Metabolic SyndromeDiabetes mellitus (DM) is a progressive, chronic metabolic disorder characterized by high oxidative stress, which can lead to cardiac damage. Methionine sulfoxylation (MetO) of proteins by excessive reactive oxygen species (ROS) can impair the basic ...
Seung Hee Lee +13 more
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Evidence for the dimerization-mediated catalysis of methionine sulfoxide reductase A from Clostridium oremlandii. [PDF]
PLoS ONE, 2015 Clostridium oremlandii MsrA (CoMsrA) is a natively selenocysteine-containing methionine-S-sulfoxide reductase and classified into a 1-Cys type MsrA. CoMsrA exists as a monomer in solution.
Eun Hye Lee +6 more
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Redox Report, 2023 Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park +2 more
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