Results 31 to 40 of about 7,593 (119)

Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. [PDF]

PLoS ONE, 2013
Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological conditions. Organisms evolved two distinct methionine sulfoxide reductase families (MSRA & MSRB) to repair oxidized methionine residues.
Dung Tien Le, Lionel Tarrago, Yasuko Watanabe, Alaattin Kaya, Byung Cheon Lee, Uyen Tran, Rie Nishiyama, Dmitri E Fomenko, Vadim N Gladyshev, Lam-Son Phan Tran   +9 more
doaj   +1 more source

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription

Redox Biology, 2018
Objective: Reduction of oxidized methionines is emerging as a major protein repair pathway. The lack of methionine sulfoxide reductase A (MsrA) exacerbates cardiovascular disease phenotypes driven by increased oxidative stress.
Steven M. Pennington, Paula R. Klutho, Litao Xie, Kim Broadhurst, Olha M. Koval, Michael L. McCormick, Douglas R. Spitz, Isabella M. Grumbach   +7 more
doaj   +1 more source

Novel Mechanism for Scavenging of Hypochlorite Involving a Periplasmic Methionine-Rich Peptide and Methionine Sulfoxide Reductase

mBio, 2015
Reactive chlorine species (RCS) defense mechanisms are important for bacterial fitness in diverse environments. In addition to the anthropogenic use of RCS in the form of bleach, these compounds are also produced naturally through photochemical reactions
Ryan A. Melnyk, Matthew D. Youngblut, Iain C. Clark, Hans K. Carlson, Kelly M. Wetmore, Morgan N. Price, Anthony T. Iavarone, Adam M. Deutschbauer, Adam P. Arkin, John D. Coates   +9 more
doaj   +1 more source

Methionine sulfoxide reductase A (MsrA) deficient Mycoplasma genitalium shows decreased interactions with host cells. [PDF]

PLoS ONE, 2012
Mycoplasma genitalium is an important sexually transmitted pathogen that affects both men and women. In genital-mucosal tissues, it initiates colonization of epithelial cells by attaching itself to host cells via several identified bacterial ligands and ...
Kishore Das, Georgina De la Garza, Shivani Maffi, Sankaralingam Saikolappan, Subramanian Dhandayuthapani   +4 more
doaj   +1 more source

The MsrAB reducing pathway of Streptococcus gordonii is needed for oxidative stress tolerance, biofilm formation, and oral colonization in mice.

PLoS ONE, 2020
The ability of Streptococcus gordonii to cope with oxidative stress is important for survival and persistence in dental plaque. In this study, we used mutational, phenotypic, and biochemical approaches to characterize the role of a methionine sulfoxide ...
Naif Jalal, Song F Lee
doaj   +1 more source

Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages. [PDF]

PLoS ONE, 2013
Leishmania are protozoan parasites that proliferate within the phagolysome of mammalian macrophages. While a number of anti-oxidant systems in these parasites have been shown to protect against endogenous as well as host-generated reactive oxygen species,
Fiona M Sansom, Leonie Tang, Julie E Ralton, Eleanor C Saunders, Thomas Naderer, Malcolm J McConville   +5 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Changes in the Levels of Methionine Adenosyltransferase, Methionine Sulfoxide Reductase A, and Thioredoxin are Associated with Oxidative Stress in Patients with Hyperthyroidism

Diyala Journal of Medicine
Background: Hyperthyroidism is associated with increased oxidative stress and alterations in enzymatic and non-enzymatic antioxidant systems. Methionine adenosyltransferase (MAT) plays a key role in cellular metabolism and may be involved in redox ...
Marwa A. Al-Badrany, Luay A. Al-Helaly
doaj   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source