The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria [PDF]
Antioxidants, 2018 Methionine sulfoxide reductases (MSRA1 and MSRB) are proteins overproduced in Staphylococcus aureus during exposure with cell wall-active antibiotics. Later studies identified the presence of two additional MSRA proteins (MSRA2 and MSRA3) in S.
Vineet K. Singh +2 more
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Role of ClpX and MsrA/B in the Oxidative and Cell Wall Stress Response in Bacillus anthracis Sterne [PDF]
MicrobiologyOpenClpX functions as a component of the ClpXP protease, a conserved intracellular protease that regulates protein turnover, stress responses, and virulence in multiple bacterial species.
Aeron B. Pennington +5 more
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Differential Responses of Methionine Sulfoxide Reductases A and B to Anoxia and Oxidative Stress in the Freshwater Turtle Trachemys scripta [PDF]
Metabolites, 2021 Oxidative stress has been acknowledged as a major factor in aging, senescence and neurodegenerative conditions. Mammalian models are susceptible to these stresses following the restoration of oxygen after anoxia; however, some organisms including the ...
Melissa Reiterer +2 more
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Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. [PDF]
PLoS ONE, 2013 Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological conditions. Organisms evolved two distinct methionine sulfoxide reductase families (MSRA & MSRB) to repair oxidized methionine residues.
Dung Tien Le +9 more
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Expression of Four Methionine Sulfoxide Reductases in Staphylococcus aureus [PDF]
International Journal of Microbiology, 2012 Staphylococcus aureus possesses three MsrA enzymes (MsrA1, MsrA2, MsrA3) that reduce the S-epimer of methionine sulfoxide (MetO) and an MsrB enzyme that reduces R-MetO. The four msr genes are expressed from three different promoters.
Kuldeep Singh, Vineet K. Singh
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Regulation of Expression of Oxacillin-Inducible Methionine Sulfoxide Reductases in Staphylococcus aureus [PDF]
International Journal of Microbiology, 2015 Cell wall-active antibiotics cause induction of a locus that leads to elevated synthesis of two methionine sulfoxide reductases (MsrA1 and MsrB) in Staphylococcus aureus.
Kyle R. Baum +2 more
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Methionine Residues in Exoproteins and Their Recycling by Methionine Sulfoxide Reductase AB Serve as an Antioxidant Strategy in Bacillus cereus [PDF]
Frontiers in Microbiology, 2017 During aerobic respiratory growth, Bacillus cereus is exposed to continuously reactive oxidant, produced by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS).
Jean-Paul Madeira +4 more
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In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster
Antioxidants, 2018 The deleterious alteration of protein structure and function due to the oxidation of methionine residues has been studied extensively in age-associated neurodegenerative disorders such as Alzheimer’s and Parkinson’s Disease.
Lindsay Bruce +7 more
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Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in
BMC Microbiology, 2008 Background All aerobically grown living cells are exposed to oxidative damage by reactive oxygen species (ROS). A major damage by ROS to proteins is caused by covalent modifications of methionine residues giving methionine sulfoxide (Met-SO).
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Identification of activators of methionine sulfoxide reductases A and B [PDF]
Biochemical and Biophysical Research Communications, 2016 Maciej J Stawikowski +2 more
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